Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Teasdale, J. D. Articles by Checkley, S. A. Search for Related Content PubMed Citation Articles by Teasdale, J. D. Articles by Checkley, S. A. Neuropsychology MRI

Functional MRI Study of the Cognitive Generation of Affect

OBJECTIVE: The authors investigated, by whole brain functional magnetic resonance imaging (MRI), the neural substrate underlying processing of emotion-related meanings. METHOD: Six healthy subjects underwent functional MRI while viewing 1) alternating blocks of pairs of pictures and captions evoking negative feelings and the same materials irrelevantly paired to produce less emotion (reference pairs); 2) alternating blocks of picture-caption pairs evoking positive feelings and the same materials irrelevantly paired to produce less emotion; and 3) alternating blocks of picture-caption pairs evoking positive feelings and picture-caption pairs evoking negative feelings. RESULTS: Compared with the reference picture-caption pairs, negative pairs activated the right medial and middle frontal gyri, right anterior cingulate gyrus, and right thalamus. Compared with the reference picture-caption pairs, positive pairs activated the right and left insula, right inferior frontal gyrus, left splenium, and left precuneus. Compared with the negative picture-caption pairs, positive pairs activated the right and left medial frontal gyri, right anterior cingulate gyrus, right precentral gyrus, and left caudate. CONCLUSIONS: Contrasts of both 1) negative and reference picture-caption pairs and 2) positive and negative picture-caption pairs activated networks involving similar areas in the medial frontal gyrus (Brodmann's area 9) and right anterior cingulate gyrus (areas 24 and 32). The area 9 sites activated are strikingly similar to sites activated in related positron emission tomography experiments. Activation of these same sites by a range of evoked affects, elicited by different methods, is consistent with areas within the medial prefrontal cortex mediating the processing of affect-related meanings, a process common to many forms of emotion production.

This article has been cited by other articles:

				P. Tavares, A. D. Lawrence, and P. J. Barnard Paying Attention to Social Meaning: An fMRI Study Cereb Cortex, August 1, 2008; 18(8): 1876 - 1885. [Abstract] [Full Text] [PDF]

				S. H. Kennedy, J. Z. Konarski, Z. V. Segal, M. A. Lau, P. J. Bieling, R. S. McIntyre, and H. S. Mayberg Differences in Brain Glucose Metabolism Between Responders to CBT and Venlafaxine in a 16-Week Randomized Controlled Trial Am J Psychiatry, May 1, 2007; 164(5): 778 - 788. [Abstract] [Full Text] [PDF]

				R. B. Postuma and A. Dagher Basal Ganglia Functional Connectivity Based on a Meta-Analysis of 126 Positron Emission Tomography and Functional Magnetic Resonance Imaging Publications Cereb Cortex, October 1, 2006; 16(10): 1508 - 1521. [Abstract] [Full Text] [PDF]

				U. Habel, M. Klein, N. J. Shah, I. Toni, K. Zilles, P. Falkai, and F. Schneider Genetic Load on Amygdala Hypofunction During Sadness in Nonaffected Brothers of Schizophrenia Patients Am J Psychiatry, October 1, 2004; 161(10): 1806 - 1813. [Abstract] [Full Text] [PDF]

				D. Mataix-Cols, S. Wooderson, N. Lawrence, M. J. Brammer, A. Speckens, and M. L. Phillips Distinct Neural Correlates of Washing, Checking, and Hoarding Symptom Dimensions in Obsessive-compulsive Disorder Arch Gen Psychiatry, June 1, 2004; 61(6): 564 - 576. [Abstract] [Full Text] [PDF]

				H. Gundel, A. Lopez-Sala, A. O. Ceballos-Baumann, J. Deus, N. Cardoner, B. Marten-Mittag, C. Soriano-Mas, and J. Pujol Alexithymia Correlates With the Size of the Right Anterior Cingulate Psychosom Med, January 1, 2004; 66(1): 132 - 140. [Abstract] [Full Text] [PDF]

				P. Fossati, S. J. Hevenor, S. J. Graham, C. Grady, M. L. Keightley, F. Craik, and H. Mayberg In Search of the Emotional Self: An fMRI Study Using Positive and Negative Emotional Words Am J Psychiatry, November 1, 2003; 160(11): 1938 - 1945. [Abstract] [Full Text] [PDF]

				H. Gundel, M.-F. O'Connor, L. Littrell, C. Fort, and R. D. Lane Functional Neuroanatomy of Grief: An fMRI Study Am J Psychiatry, November 1, 2003; 160(11): 1946 - 1953. [Abstract] [Full Text] [PDF]

				S. Paradiso, R. G. Robinson, L. L. Boles Ponto, G. L. Watkins, and R. D. Hichwa Regional Cerebral Blood Flow Changes During Visually Induced Subjective Sadness in Healthy Elderly Persons J Neuropsychiatry Clin Neurosci, February 1, 2003; 15(1): 35 - 44. [Abstract] [Full Text] [PDF]

				I. M. GOODYER Social adversity and mental functions in adolescents at high risk of psychopathology: Position paper and suggested framework for future research The British Journal of Psychiatry, November 1, 2002; 181(5): 383 - 386. [Abstract] [Full Text] [PDF]

				S. Berthoz, E. Artiges, P.-F. Van de Moortele, J.-B. Poline, S. Rouquette, S. M. Consoli, and J.-L. Martinot Effect of Impaired Recognition and Expression of Emotions on Frontocingulate Cortices: An fMRI Study of Men With Alexithymia Am J Psychiatry, June 1, 2002; 159(6): 961 - 967. [Abstract] [Full Text] [PDF]

				I. Liberzon, J. K. Zubieta, L. M. Fig, K. L. Phan, R. A. Koeppe, and S. F. Taylor {micro}-Opioid receptors and limbic responses to aversive emotional stimuli PNAS, May 14, 2002; 99(10): 7084 - 7089. [Abstract] [Full Text] [PDF]

				G. Weniger and E. Irle Impaired Facial Affect Recognition and Emotional Changes in Subjects with Transmodal Cortical Lesions Cereb Cortex, March 1, 2002; 12(3): 258 - 268. [Abstract] [Full Text] [PDF]

				F.C. MURPHY and B.J. SAHAKIAN Neuropsychology of bipolar disorder The British Journal of Psychiatry, June 1, 2001; 178 (41): s120 - s127. [Abstract] [Full Text] [PDF]

				M.-P. AUSTIN, P. MITCHELL, and G. M. GOODWIN Cognitive deficits in depression: Possible implications for functional neuropathology The British Journal of Psychiatry, March 1, 2001; 178(3): 200 - 206. [Abstract] [Full Text] [PDF]

				B. E. Wexler, C. H. Gottschalk, R. K. Fulbright, I. Prohovnik, C. M. Lacadie, B. J. Rounsaville, and J. C. Gore Functional Magnetic Resonance Imaging of Cocaine Craving Am J Psychiatry, January 1, 2001; 158(1): 86 - 95. [Abstract] [Full Text]

				J.-K. Zubieta, P. Huguelet, L. E. Ohl, R. A. Koeppe, M. R. Kilbourn, J. M. Carr, B. J. Giordani, and K. A. Frey High Vesicular Monoamine Transporter Binding in Asymptomatic Bipolar I Disorder: Sex Differences and Cognitive Correlates Am J Psychiatry, October 1, 2000; 157(10): 1619 - 1628. [Abstract] [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 1999 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us