Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Zubenko, G. S. Articles by Martinez, A. J. Search for Related Content PubMed Citation Articles by Zubenko, G. S. Articles by Martinez, A. J. Alzheimer's Disease Genetics

Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years

OBJECTIVE: The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer's disease and its relationship to the APOE 4 genotype. METHOD: This report describes the results of a prospective, longitudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's disease. RESULTS: Nine incident cases of Alzheimer's disease were detected during the first 2,220 subject-years of the follow-up period. Age, increased platelet membrane fluidity, and the APOE 4 allele made significant independent contributions to the risk of developing Alzheimer's disease, while sex and years of education did not. Increased platelet membrane fluidity was associated with incident Alzheimer's disease cases between the ages of 64 and 71, while the 4 allele was associated with incident Alzheimer's disease cases from age 64 until at least age 80. CONCLUSIONS: These results indicate that increased platelet membrane fluidity is not produced by the APOE 4 allele. Instead, increased platelet membrane fluidity and the 4 allele appear to make significant independent contributions to the risk of developing Alzheimer's disease among the first-degree relatives of patients with this disorder. Moreover, the age ranges over which these risk factors operate appear to be different.

This article has been cited by other articles:

				S. A. FARBER, B. E. SLACK, and J. K. BLUSZTAJN Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease FASEB J, November 1, 2000; 14(14): 2198 - 2206. [Abstract] [Full Text]

				G. M. Halliday, C. E. Shepherd, H. McCann, W. G. J. Reid, D. A. Grayson, G. A. Broe, and J. J. Kril Effect of Anti-inflammatory Medications on Neuropathological Findings in Alzheimer Disease Arch Neurol, June 1, 2000; 57(6): 831 - 836. [Abstract] [Full Text] [PDF]

				G. S. Zubenko, H. B. Hughes III, and J. S. Stiffler Neurobiological correlates of a putative risk allele for Alzheimer's disease on chromosome 12q Neurology, March 1, 1999; 52(4): 725 - 725. [Abstract] [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 1999 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us