Am J Psychiatry 155:1278-1280, September 1998
©Copyright 1998 American Psychiatric Association
Pilot Study of the Cytochrome P450-2D6 Genotype in a Psychiatric State Hospital
Jose de Leon, M.D.,
John Barnhill, M.D.,
Thea Rogers, Pharm.D.,
Jenni Boyle, B.S.,
Wen-Hwei Chou, Pharm.D., and
Peter J. Wedlund, Ph.D.
Objective: The authors conducted a pilot study to develop preliminary data on the frequency of cytochrome P450-2D6 (CYP2D6) genotypes in state psychiatric hospital patients and to establish population sizes needed to determine potential clinical relevance in therapeutic outcome.Method: One hundred consecutive inpatients at Eastern State Hospital in Kentucky who provided informed consent were genotyped at the CYP2D6 locus during their hospital stay.Results: Twelve of the patients were CYP2D6 deficient, and four carried the *1Xn or *2Xn allele associated with ultrarapid metabolism; all of these patients were Caucasian (N=87). The rate of deficiency in CYP2D6 expression in these Caucasian state psychiatric hospital patients (14%) was twice that of the U.S. population (7%). The patients with CYP2D6 deficiency also appeared more likely to experience side effects in response to CYP2D6 medications.Conclusions: This study, limited by a small number of subjects, suggests that one-fifth of Caucasians admitted to a state hospital in Kentucky had genotypes associated with extremes in CYP2D6 activity that may have affected their response to CYP2D6 medications. Am J Psychiatry 1998; 155: 1278-1280
This article has been cited by other articles:
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J. de Leon, S. C. Armstrong, and K. L. Cozza
Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19.
Psychosomatics,
January 1, 2006;
47(1):
75 - 85.
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