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CO₂-Induced Panic Attacks: A Twin Study

Objective: The authors investigated the role of genetic factors in 35% CO₂-induced panic attacks.Method: Ninety twins recruited from general population were challenged with one-vital capacity inhalations of 35% CO₂–65% O₂. Probandwise concordance rates were calculated and rates compared for monozygotic and for dizygotic twins.Results: A significantly higher concordance was found for 35% CO₂-induced panic attacks among monozygotic than dizygotic twins (55.6% versus 12.5%).Conclusions: These results suggest a relevant role of genetic factors in 35% CO₂-induced panic attacks. Am J Psychiatry 1998; 155: 1184-1188

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