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Serum Anticholinergicity in Elderly Depressed Patients Treated With Paroxetine or Nortriptyline

OBJECTIVE: The authors' goal was to compare serum anticholinergicity of 61 elderly depressed patients randomly assigned to double-blind treatment with paroxetine (N=31) or nortriptyline (N=30). METHOD: Both antidepressants were titrated in a standardized manner, and plasma was sampled weekly for measurement of paroxetine and nortriptyline and its hydroxy metabolite concentrations. Serum anticholinergicity was measured at baseline and after 1, 4, and 6 weeks of treatment. Side effects were assessed by using a validated scale. RESULTS: After correcting for pretreatment anticholinergicity, the authors found that mean serum anticholinergicity for the nortriptyline-treated patients was significantly greater than that for the paroxetine group at all weeks assessed. Serum anticholinergicity was significantly correlated with nortriptyline but not with paroxetine plasma levels. Complaints of dry mouth and tachycardia were significantly more frequent and severe in the nortriptyline group. CONCLUSIONS: These findings suggest that, at therapeutic plasma concentrations, paroxetine has approximately one-fifth the anticholinergic potential of nortriptyline in older patients. (Am J Psychiatry 1998; 155:1110–1112)

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				References PsychiatryOnline CME, May 1, 2007; 2007(1): 2 - 2. [Full Text]

				F. E. Lotrich and B. G. Pollock Aging and Clinical Pharmacology: Implications for Antidepressants J. Clin. Pharmacol., October 1, 2005; 45(10): 1106 - 1122. [Abstract] [Full Text] [PDF]

				M. A. Butters, E. M. Whyte, R. D. Nebes, A. E. Begley, M. A. Dew, B. H. Mulsant, M. D. Zmuda, R. Bhalla, C. C. Meltzer, B. G. Pollock, et al. The Nature and Determinants of Neuropsychological Functioning in Late-Life Depression Arch Gen Psychiatry, June 1, 2004; 61(6): 587 - 595. [Abstract] [Full Text] [PDF]

				B. H. Mulsant, B. G. Pollock, M. Kirshner, C. Shen, H. Dodge, and M. Ganguli Serum Anticholinergic Activity in a Community-Based Sample of Older Adults: Relationship With Cognitive Performance Arch Gen Psychiatry, February 1, 2003; 60(2): 198 - 203. [Abstract] [Full Text] [PDF]

				B. H. Mulsant, B. G. Pollock, R. Nebes, M. D. Miller, R. A. Sweet, J. Stack, P. R. Houck, S. Bensasi, S. Mazumdar, and C. F. Reynolds III A Twelve-Week, Double-Blind, Randomized Comparison of Nortriptyline and Paroxetine in Older Depressed Inpatients and Outpatients Am J Geriatr Psychiatry, November 1, 2001; 9(4): 406 - 414. [Abstract] [Full Text] [PDF]

				P. M. Furlan, M. J. Kallan, T. Ten Have, B. G. Pollock, I. Katz, and I. Lucki Cognitive and Psychomotor Effects of Paroxetine and Sertraline on Healthy Elderly Volunteers Am J Geriatr Psychiatry, November 1, 2001; 9(4): 429 - 438. [Abstract] [Full Text] [PDF]

				L. Han, J. McCusker, M. Cole, M. Abrahamowicz, F. Primeau, and M. Elie Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients Arch Intern Med, April 23, 2001; 161(8): 1099 - 1105. [Abstract] [Full Text] [PDF]

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