Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Malison, R. T. Articles by Innis, R. B. Search for Related Content PubMed Citation Articles by Malison, R. T. Articles by Innis, R. B.

Elevated Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by [¹²³I]ß-CIT SPECT

OBJECTIVE: The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies. METHOD: [¹²³I]ß-CIT and single photon emission computed tomography were used to assess striatal dopamine transporter levels in 28 cocaine-abusing subjects and 24 comparison subjects matched as a group for age and gender. RESULTS: Results showed a significant (approximately 20%) elevation in striatal V₃'' values in acutely abstinent cocaine-abusing subjects relative to comparison subjects. An inverse correlation between dopamine transporter level and Hamilton Depression Rating Scale score was also observed. CONCLUSIONS: These findings indicate more modest elevations in striatal dopamine transporters in cocaine-abusing subjects than noted in previous postmortem reports and suggest a possible relationship between cocaine-related depression and dopamine transporter binding.

This article has been cited by other articles:

				E. M. van de Giessen, M. M.L. de Win, M. W.T. Tanck, W. van den Brink, F. Baas, and J. Booij Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3 J. Nucl. Med., January 1, 2009; 50(1): 45 - 52. [Abstract] [Full Text] [PDF]

				D. C. Mash, Q. Ouyang, J. Pablo, M. Basile, S. Izenwasser, A. Lieberman, and R. J. Perrin Cocaine Abusers Have an Overexpression of alpha -Synuclein in Dopamine Neurons J. Neurosci., April 1, 2003; 23(7): 2564 - 2571. [Abstract] [Full Text] [PDF]

				A. Roy, J. Berman, R. Williams, C. Kuhn, and B. Gonzalez Higher Levels of CSF Homovanillic Acid in Recently Abstinent Cocaine-Dependent Patients Am J Psychiatry, June 1, 2002; 159(6): 1053 - 1055. [Abstract] [Full Text] [PDF]

				C. H. van Dyck, D. M. Quinlan, L. M. Cretella, J. K. Staley, R. T. Malison, R. M. Baldwin, J. P. Seibyl, and R. B. Innis Unaltered Dopamine Transporter Availability in Adult Attention Deficit Hyperactivity Disorder Am J Psychiatry, February 1, 2002; 159(2): 309 - 312. [Abstract] [Full Text] [PDF]

				N. D. Volkow, L. Chang, G.-J. Wang, J. S. Fowler, D. Franceschi, M. Sedler, S. J. Gatley, E. Miller, R. Hitzemann, Y.-S. Ding, et al. Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence J. Neurosci., December 1, 2001; 21(23): 9414 - 9418. [Abstract] [Full Text] [PDF]

				A. Janowsky, C. Mah, R. A. Johnson, C. L. Cunningham, T. J. Phillips, J. C. Crabbe, A. J. Eshleman, and J. K. Belknap Mapping Genes That Regulate Density of Dopamine Transporters and Correlated Behaviors in Recombinant Inbred Mice J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 634 - 643. [Abstract] [Full Text] [PDF]

				T. P. J. Laine, A. Ahonen, P. Rasanen, T. Pohjalainen, J. Tiihonen, and J. Hietala The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics Alcohol Alcohol., May 1, 2001; 36(3): 262 - 265. [Abstract] [Full Text] [PDF]

				S. R. Letchworth, M. A. Nader, H. R. Smith, D. P. Friedman, and L. J. Porrino Progression of Changes in Dopamine Transporter Binding Site Density as a Result of Cocaine Self-Administration in Rhesus Monkeys J. Neurosci., April 15, 2001; 21(8): 2799 - 2807. [Abstract] [Full Text] [PDF]

				L. K. Jacobsen, J. K. Staley, R. T. Malison, S. S. Zoghbi, J. P. Seibyl, T. R. Kosten, and R. B. Innis Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients Am J Psychiatry, July 1, 2000; 157(7): 1134 - 1140. [Abstract] [Full Text]

				U. D. McCann, D. F. Wong, F. Yokoi, V. Villemagne, R. F. Dannals, and G. A. Ricaurte Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428 J. Neurosci., October 15, 1998; 18(20): 8417 - 8422. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1998 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us