Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Kwon, J. S. Articles by McCarley, R. W. Search for Related Content PubMed Citation Articles by Kwon, J. S. Articles by McCarley, R. W.

MRI Study of Cavum Septi Pellucidi in Schizophrenia, Affective Disorder, and Schizotypal Personality Disorder

OBJECTIVE: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of the brain. The authors examined cavum septi pellucidi in subjects with schizophrenia, affective disorder, and schizotypal personality disorder and in normal subjects. METHOD: Thirty schizophrenic patients (15 chronic, 15 first-episode), 16 patients with affective disorder (first-episode), 21 patients with schizotypal personality disorder, and 46 normal subjects were evaluated with magnetic resonance imaging. Cavum septi pellucidi was assessed by counting the number of 1.5-mm slices containing cavum septi pellucidi. RESULTS: The presence or absence of cavum septi pellucidi did not differentiate among groups. However, the prevalence of abnormal cavum septi pellucidi (i.e., cavum septi pellucidi contained on four or more slices) was 30.4% for schizophrenic patients (36.4% for chronic, 25.0% for first-episode), 20.0% for patients with affective disorder, 18.8% for patients with schizotypal personality disorder, and 10.3% for normal subjects. When the authors used the Nopoulos et al. criteria for rating cavum septi pellucidi, which omitted borderline cases with cavum septi pellucidi on three slices, the prevalence of abnormal cavum septi pellucidi increased to 35.0% for schizophrenia (40.0% for chronic, 30.0% for first-episode), 25.0% for affective disorder, 27.3% for schizotypal personality disorder, and 13.0% for normal subjects. There was a statistically significant difference in ratings between schizophrenic and normal subjects. CONCLUSIONS: The results suggest that alterations in midline structures during the course of neurodevelopment may play a role in the pathogenesis of schizophrenia.

This article has been cited by other articles:

				M.-S. Koo, C. C. Dickey, H.-J. Park, M. Kubicki, N. Y. Ji, S. Bouix, K. M. Pohl, J. J. Levitt, M. Nakamura, M. E. Shenton, et al. Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder. Arch Gen Psychiatry, October 1, 2006; 63(10): 1090 - 1100. [Abstract] [Full Text] [PDF]

				S J Borgwardt, E-W Radue, K Gotz, J Aston, M Drewe, U Gschwandtner, S Haller, M Pfluger, R-D Stieglitz, P K McGuire, et al. Radiological findings in individuals at high risk of psychosis J. Neurol. Neurosurg. Psychiatry, February 1, 2006; 77(2): 229 - 233. [Abstract] [Full Text] [PDF]

				M. Epelman, A. Daneman, S. I. Blaser, C. Ortiz-Neira, O. Konen, J. Jarrin, and O. M. Navarro Differential Diagnosis of Intracranial Cystic Lesions at Head US: Correlation with CT and MR Imaging RadioGraphics, January 1, 2006; 26(1): 173 - 196. [Abstract] [Full Text] [PDF]

				C. Pantelis, M. Yucel, S. J Wood, D. Velakoulis, D. Sun, G. Berger, G. W Stuart, A. Yung, L. Phillips, and P. D McGorry Structural Brain Imaging Evidence for Multiple Pathological Processes at Different Stages of Brain Development in Schizophrenia Schizophr Bull, July 1, 2005; 31(3): 672 - 696. [Abstract] [Full Text] [PDF]

				L. J. Siever and K. L. Davis The Pathophysiology of Schizophrenia Disorders: Perspectives From the Spectrum Am J Psychiatry, March 1, 2004; 161(3): 398 - 413. [Abstract] [Full Text] [PDF]

				M. Galarza, A. B. Merlo, A. Ingratta, E. F. Albanese, and A. M. Albanese Cavum Septum Pellucidum and Its Increased Prevalence in Schizophrenia: A Neuroembryological Classification J Neuropsychiatry Clin Neurosci, February 1, 2004; 16(1): 41 - 46. [Abstract] [Full Text] [PDF]

				C. C. Dickey, R. W. McCarley, M. M. Voglmaier, M. Frumin, M. A. Niznikiewicz, Y. Hirayasu, S. Fraone, L. J. Seidman, and M. E. Shenton Smaller Left Heschl's Gyrus Volume in Patients With Schizotypal Personality Disorder Am J Psychiatry, September 1, 2002; 159(9): 1521 - 1527. [Abstract] [Full Text] [PDF]

				H. Hagino, M. Suzuki, K. Kurokawa, K. Mori, S. Nohara, T. Takahashi, I. Yamashita, T. Yotsutsuji, M. Kurachi, and H. Seto Magnetic Resonance Imaging Study of the Cavum Septi Pellucidi in Patients With Schizophrenia Am J Psychiatry, October 1, 2001; 158(10): 1717 - 1719. [Abstract] [Full Text] [PDF]

				P. Nopoulos, A. Krie, and N. C. Andreasen Enlarged Cavum Septi Pellucidi in Patients With Schizophrenia: Clinical and Cognitive Correlates J Neuropsychiatry Clin Neurosci, August 1, 2000; 12(3): 344 - 349. [Abstract] [Full Text]

				P. J. Harrison The neuropathology of schizophrenia: A critical review of the data and their interpretation Brain, April 1, 1999; 122(4): 593 - 624. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1998 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us