Am J Psychiatry 155:373-379, March 1998
© 1998 American Psychiatric Association
Selective Alteration of Personality and Social Behavior by Serotonergic Intervention
Brian Knutson, Ph.D.,
Owen M. Wolkowitz, M.D.,
Steve W. Cole, Ph.D.,
Theresa Chan, B.A.,
Elizabeth A. Moore, Ph.D.,
Ronald C. Johnson, Ph.D.,
Jan Terpstra, M.D.,
Rebecca A. Turner, Ph.D., and
Victor I. Reus, M.D.
OBJECTIVE: The authors sought to test the causal hypothesis that serotonergic function modulates aspects of the normal spectrum of individual differences in affective experience and social behavior in humans. METHOD: A selective serotonin reuptake inhibitor (SSRI), paroxetine, 20 mg/day (N=26), or placebo (N=25) was administered to normal volunteers in a double-blind manner for 4 weeks, and personality variables and social behavior were assessed at baseline and at weeks 1 and 4 of treatment. RESULTS: Relative to placebo, SSRI administration reduced focal indices of hostility through a more general decrease in negative affect, yet did not alter indices of positive affect. In addition, SSRI administration increased a behavioral index of social affiliation. Changes in both negative affect and affiliative behavior were significantly related to volunteers' plasma SSRI levels at the end of the experiment. CONCLUSIONS: Central serotonergic function may modulate a dimension of normal personality characterized by reduced negative affective experience and increased affiliative behavior. SSRI administration has significant and detectable effects on these measures even in the absence of baseline clinical depression or other psychopathology.
This article has been cited by other articles:
|
|
|
|
 
L. G. Crisan, S. Pana, R. Vulturar, R. M. Heilman, R. Szekely, B. Druga, N. Dragos, and A. C. Miu
Genetic contributions of the serotonin transporter to social learning of fear and economic decision making
Soc Cogn Affect Neurosci,
June 17, 2009;
(2009)
nsp019v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Gillath, P. R. Shaver, J.-M. Baek, and D. S. Chun
Genetic Correlates of Adult Attachment Style
Pers Soc Psychol Bull,
October 1, 2008;
34(10):
1396 - 1405.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. J. van der Wee, J. F. van Veen, H. Stevens, I. M. van Vliet, P. P. van Rijk, and H. G. Westenberg
Increased Serotonin and Dopamine Transporter Binding in Psychotropic Medication-Naive Patients with Generalized Social Anxiety Disorder Shown by 123I-{beta}-(4-Iodophenyl)-Tropane SPECT
J. Nucl. Med.,
May 1, 2008;
49(5):
757 - 763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. V. Curran and K. Robjant
Eating attitudes, weight concerns and beliefs about drug effects in women who use ecstasy
J Psychopharmacol,
May 1, 2006;
20(3):
425 - 431.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Chatterjee
The promise and predicament of cosmetic neurology
J. Med. Ethics,
February 1, 2006;
32(2):
110 - 113.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Liebowitz, A. J. Gelenberg, and D. Munjack
Venlafaxine Extended Release vs Placebo and Paroxetine in Social Anxiety Disorder
Arch Gen Psychiatry,
February 1, 2005;
62(2):
190 - 198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Harmer, N. C. Shelley, P. J. Cowen, and G. M. Goodwin
Increased Positive Versus Negative Affective Perception and Memory in Healthy Volunteers Following Selective Serotonin and Norepinephrine Reuptake Inhibition
Am J Psychiatry,
July 1, 2004;
161(7):
1256 - 1263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Krakowski
Violence and Serotonin: Influence of Impulse Control, Affect Regulation, and Social Functioning
J Neuropsychiatry Clin Neurosci,
August 1, 2003;
15(3):
294 - 305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Tse and A. J. Bond
Reboxetine Promotes Social Bonding in Healthy Volunteers
J Psychopharmacol,
June 1, 2003;
17(2):
189 - 195.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. C. Dolan and I. M. Anderson
The Relationship between Serotonergic Function and the Psychopathy Checklist: Screening Version
J Psychopharmacol,
June 1, 2003;
17(2):
216 - 222.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. J. Harmer, S. A. Hill, M. J. Taylor, P. J. Cowen, and G. M. Goodwin
Toward a Neuropsychological Theory of Antidepressant Drug Action: Increase in Positive Emotional Bias After Potentiation of Norepinephrine Activity
Am J Psychiatry,
May 1, 2003;
160(5):
990 - 992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.G. Charlton
The potential for pharmacological treatment of unpleasant psychological symptoms to increase personal fulfillment in old age
QJM,
June 1, 2001;
94(6):
333 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Tse and A. J. Bond
Serotonergic involvement in the psychosocial dimension of personality
J Psychopharmacol,
May 1, 2001;
15(3):
195 - 198.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. P. Mendoza and J. D. Ruys
The beginning of an alternative view of the neurobiology of emotion
Social Science Information,
March 1, 2001;
40(1):
39 - 60.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. J. M. H. Strik, A. Honig, R. Lousberg, A. H. P. Lousberg, E. C. Cheriex, H. G. Tuynman-Qua, P. M. J. C. Kuijpers, H. J. J. Wellens, and H. M. Van Praag
Efficacy and Safety of Fluoxetine in the Treatment of Patients With Major Depression After First Myocardial Infarction: Findings From a Double-Blind, Placebo-Controlled Trial
Psychosom Med,
December 1, 2000;
62(6):
783 - 789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Fann, J. M. Uomoto, and W. J. Katon
Sertraline in the Treatment of Major Depression Following Mild Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci,
May 1, 2000;
12(2):
226 - 232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. F. Krueger
The Structure of Common Mental Disorders
Arch Gen Psychiatry,
October 1, 1999;
56(10):
921 - 926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Volavka
The Neurobiology of Violence: An Update
J Neuropsychiatry Clin Neurosci,
August 1, 1999;
11(3):
307 - 314.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. BALON
Alteration of Personality by Serotonergic Intervention
Am J Psychiatry,
June 1, 1999;
156(6):
985 - 985.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1998
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
