Am J Psychiatry 155:1784-1786, December 1998
©Copyright 1998 American Psychiatric Association
Partial Volume Decrease of the Thalamus in Relatives of Patients With Schizophrenia
Wouter G. Staal, M.D.,
Hilleke E. Hulshoff Pol, Ph.D.,
Hugo Schnack, Ph.D.,
Astrid C. van der Schot, M.S., and
René S. Kahn, M.D., Ph.D.
Objective:The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.Method:Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects. Results:Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.Conclusions:These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives. Am J Psychiatry 1998; 155: 1784-1786
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