Am J Psychiatry 155:1490-1501, November 1998
©Copyright 1998 American Psychiatric Association
Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory Findings
Gregory W. Dalack, M.D.,
Daniel J. Healy, M.D., and
James H. Meador-Woodruff, M.D.
Objective:The goal of this report is to examine the potential implications of the high prevalence of smoking in schizophrenia for our understanding of this illness.Method:A selective review of the relevant clinical and preclinical literature was conducted. The authors present a review of the clinical observations about smoking in schizophrenia, summarize the preclinical data about the complexity of the CNS nicotinic receptor family, and examine the modulatory effects of nicotine on neurotransmitter systems implicated in schizophrenia.Results:Clinical data suggest that smoking in schizophrenia may represent an attempt to self-medicate symptoms of the illness. Preclinical findings support a potential role of nicotine in medicating negative symptoms in particular. Recent preclinical and clinical data suggest that schizophrenic patients have a primary defect in the CNS nicotinergic system that leads to abnormal sensory gating. The complexity of the neuromodulatory effects of CNS nicotinic systems on other neurotransmitter systems underscores both the scope and potential importance of continued advancement of research in this area.Conclusions:Despite increasing clinical research focused on the extremely high prevalence of smoking in schizophrenia, linkages to the prodigious preclinical data about nicotine and nicotinic receptors are largely unexplored. These linkages are likely to be very important. Integrating nicotine use into our clinical and basic models of schizophrenia leads to a more complex but more realistic representation of brain dysfunction in this illness. Understanding how and why schizophrenic individuals use nicotine may lead to the development of new treatments for both schizophrenia and nicotine dependence. Am J Psychiatry 1998; 155: 1490-1501
This article has been cited by other articles:
|
|
|
|
 
J. A. Gray and B. L. Roth
Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia
Schizophr Bull,
September 1, 2007;
33(5):
1100 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Noel
ASHP Therapeutic Position Statement on the Use of Second-Generation Antipsychotic Medications in the Treatment of Adults with Psychotic Disorders
Am. J. Health Syst. Pharm.,
April 15, 2007;
64(8):
863 - 876.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Williams and J. Foulds
Successful Tobacco Dependence Treatment in Schizophrenia
Am J Psychiatry,
February 1, 2007;
164(2):
222 - 227.
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. LEVAV, I. LIPSHITZ, I. NOVIKOV, I. PUGACHOVA, R. KOHN, M. BARCHANA, A. PONIZOVSKY, and H. WERNER
Cancer risk among parents and siblings of patients with schizophrenia
The British Journal of Psychiatry,
February 1, 2007;
190(2):
156 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Sacco, A. Termine, A. Seyal, M. M. Dudas, J. C. Vessicchio, S. Krishnan-Sarin, P. I. Jatlow, B. E. Wexler, and T. P. George
Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Arch Gen Psychiatry,
June 1, 2005;
62(6):
649 - 659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Aguilar, M. Gurpegui, F. J. Diaz, and J. De Leon
Nicotine dependence and symptoms in schizophrenia: Naturalistic study of complex interactions
The British Journal of Psychiatry,
March 1, 2005;
186(3):
215 - 221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sarter, C. L Nelson, and J. P Bruno
Cortical Cholinergic Transmission and Cortical Information Processing in Schizophrenia
Schizophr Bull,
January 1, 2005;
31(1):
117 - 138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Sacco, K. L. Bannon, and T. P. George
Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders
J Psychopharmacol,
December 1, 2004;
18(4):
457 - 474.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. J. Lawn
Systemic Barriers to Quitting Smoking among Institutionalised Public Mental Health Service Populations: A Comparison of Two Australian Sites
International Journal of Social Psychiatry,
September 1, 2004;
50(3):
204 - 215.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. B. Dixon, J. A. Kreyenbuhl, F. B. Dickerson, T. W. Donner, C. H. Brown, K. Wolheiter, L. Postrado, R. W. Goldberg, L. Fang, C. Marano, et al.
A Comparison of Type 2 Diabetes Outcomes Among Persons With and Without Severe Mental Illnesses
Psychiatr Serv,
August 1, 2004;
55(8):
892 - 900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zammit, P. Allebeck, C. Dalman, I. Lundberg, T. Hemmingsson, and G. Lewis
Investigating the Association Between Cigarette Smoking and Schizophrenia in a Cohort Study
Am J Psychiatry,
December 1, 2003;
160(12):
2216 - 2221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Spring, R. Pingitore, and D. E. McChargue
Reward Value of Cigarette Smoking for Comparably Heavy Smoking Schizophrenic, Depressed, and Nonpatient Smokers
Am J Psychiatry,
February 1, 2003;
160(2):
316 - 322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. Glassman and J. T. Bigger Jr.
Antipsychotic Drugs: Prolonged QTc Interval, Torsade de Pointes, and Sudden Death
Am J Psychiatry,
November 1, 2001;
158(11):
1774 - 1782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. CORVIN, E. O'MAHONY, M. O'REGAN, C. COMERFORD, R. O'CONNELL, N. CRADDOCK, and M. GILL
Cigarette smoking and psychotic symptoms in bipolar affective disorder
The British Journal of Psychiatry,
July 1, 2001;
179(1):
35 - 38.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Lichtermann, J. Ekelund, E. Pukkala, A. Tanskanen, and J. Lonnqvist
Incidence of Cancer Among Persons With Schizophrenia and Their Relatives
Arch Gen Psychiatry,
June 1, 2001;
58(6):
573 - 578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lucksted, L. B. Dixon, and J. B. Sembly
A Focus Group Pilot Study of Tobacco Smoking Among Psychosocial Rehabilitation Clients
Psychiatr Serv,
December 1, 2000;
51(12):
1544 - 1548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Alkondon, E. F. R. Pereira, H. M. Eisenberg, and E. X. Albuquerque
Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks
J. Neurosci.,
January 1, 2000;
20(1):
66 - 75.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. R. Lyon
A Review of the Effects of Nicotine on Schizophrenia and Antipsychotic Medications
Psychiatr Serv,
October 1, 1999;
50(10):
1346 - 1350.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1998
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
