Am J Psychiatry 155:1434-1436, October 1998
©Copyright 1998 American Psychiatric Association
Rapid Cycling in Women and Men With Bipolar Manic-Depressive Disorders
Leonardo Tondo, M.D., and
Ross J. Baldessarini, M.D.
Objective:This study investigated risks for rapid cycling, as defined by DSM-IV, in women and men with bipolar disorders. Method:The results of 10 studies with a total of 2,057 bipolar patients were meta-analyzed by pooled contingency methods. Results:The proportions of women and men among rapid-cycling cases averaged 72% and 28%, respectively, but the risk of rapid cycling was inconsistently more frequent among women (29.6%) than among men (16.5%). The mean number of episodes per year was much higher in rapid-cycling patients before and during lithium treatment but was similar in rapid-cycling men and women.Conclusions:Rapid cycling was only moderately, and inconsistently, more common in bipolar women than men. Am J Psychiatry 1998; 155: 1434-1436
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