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Am J Psychiatry 1997; 154:1070-1075
Copyright © 1997 by American Psychiatric Association
Durable power of attorney and informed consent with Alzheimer's disease patients: a clinical study
R Dukoff and T Sunderland
Geriatric Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892-1264, USA.
OBJECTIVE: Experience with a new surrogate consent system for patients with
Alzheimer's disease is reviewed. It was hypothesized that as patients'
cognitive status deteriorated, surrogate consent through a durable power of
attorney would become necessary to facilitate continued involvement in
clinical research. METHOD: The authors retrospectively reviewed the charts
of inpatients with Alzheimer's disease who participated in research between
January 1989 and December 1994 at the Geriatric Psychiatry Unit of the
National Institute of Mental Health. Seventy-nine patients were included.
The main outcome measures were the Clinical Dementia Rating, Global
Deterioration Scale for primary degenerative dementia, and Mini-Mental
State. RESULTS: Most patients were in the mild-to-moderate stage of the
illness when they chose to participate in research and assign a durable
power of attorney (96% scored 2 or less on the Clinical Dementia Rating,
and 92% scored 5 or less on the Global Deterioration Scale). On average,
the subjects participated in 3.8 (SD = 2.6) studies. For 35 patients with
multiple admissions over this period (average = 3.1 years), scores on the
Clinical Dementia Rating and Global Deterioration Scale declined by 1.0 and
1.5 points, respectively. CONCLUSIONS: The durable power of attorney allows
research participation for subjects with Alzheimer's disease at all stages.
The linchpin is assignment of a durable power of attorney in the
early-to-moderate stage of Alzheimer's disease, before subjects lose the
capacity to give informed consent. This approach could also be adapted to
patients with cognitive decline due to other debilitating diseases.
This article has been cited by other articles:
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T. Sunderland, G. Linker, N. Mirza, K. T. Putnam, D. L. Friedman, L. H. Kimmel, J. Bergeson, G. J. Manetti, M. Zimmermann, B. Tang, et al.
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289(16):
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D. Goldblatt
A messy necessary end: Health care proxies need our support
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January 23, 2001;
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D. J. Rissmiller, E. Musser, W. Rhoades, F. R. Rissmiller, and R. A. Steer
A Survey of Use of a Durable Power of Attorney to Admit Geropsychiatric Patients
Psychiatr Serv,
January 1, 2001;
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G. T. Grossberg
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