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Am J Psychiatry 1997; 154:1051-1056
Copyright © 1997 by American Psychiatric Association
An MRI study of the corpus callosum in autism
J Piven, J Bailey, BJ Ranson and S Arndt
Department of Psychiatry, University of Iowa, Iowa City, USA.
OBJECTIVE: The purpose of this study was to examine the size of subregions
of the corpus callosum in autistic individuals. METHOD: The areas of three
subregions (anterior, body, and posterior) of the corpus callosum were
examined on midsagittal magnetic resonance images of 35 autistic subjects
whose mean age was 18 years and 36 healthy comparison subjects matched on
age and IQ. RESULTS: After controlling for total brain volume, gender, and
performance IQ, the authors detected a significantly smaller size of the
body and posterior subregions of the corpus callosum in the autistic
individuals. CONCLUSIONS: In the context of recent reports of increased
brain size in autism, several possible mechanisms are considered in
exploring the significance of a smaller relative size of the corpus
callosum in autism.
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