Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons



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	Other Neuroanatomy
	Neurotransmitters
	Schizophrenia Spectrum Disorders

Am J Psychiatry 1997; 154:1013-1015
Copyright © 1997 by American Psychiatric Association

REGULAR ARTICLES

Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons

TU Woo, JL Miller and DA Lewis
Department of Psychiatry, University of Pittsburgh, PA 15213, USA.

OBJECTIVE: The purpose of this study was to test the hypothesis that abnormalities in the parvalbumin-containing subclass of local circuit neurons contribute to altered gamma-aminobutyric acid (GABA) neurotransmission in the prefrontal cortex of schizophrenic subjects. METHOD: Profile counts and somal size measures were made of parvalbumin- immunoreactive neurons in areas 9, 46, and 17 from 15 matched pairs of schizophrenic and normal comparison subjects. RESULTS: No differences in relative density, laminar distribution, or somal size of labeled neurons were found in any region. CONCLUSIONS: These findings suggest that altered GABA neurotransmission in schizophrenia is due to either abnormalities in other sub-populations of prefrontal cortical GABA neurons or abnormalities in the parvalbumin-containing subclass that could not be detected in the present study.

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