Am J Psychiatry 1997; 154:1010-1012
Copyright © 1997 by American Psychiatric Association
Cytoarchitecture of the entorhinal cortex in schizophrenia
M Akil and DA Lewis
Department of Psychiatry, University of Pittsburgh, PA 15213, USA.
OBJECTIVE: The purpose of this study was to determine whether schizophrenia
is associated with abnormalities in neuronal migration in the entorhinal
cortex. METHOD: Nissl-stained sections through three cytoarchitectonic
subdivisions of the entorhinal cortex were examined in postmortem brain
specimens from 10 schizophrenic subjects and 10 matched normal comparison
subjects. RESULTS: No qualitative differences in cytoarchitecture were
observed between the schizophrenic and comparison subjects. CONCLUSIONS:
These findings do not replicate previous reports of cytoarchitectural
disturbances in the entorhinal cortex of schizophrenic subjects and thus
fail to support the hypothesis of abnormal neuronal migration in
schizophrenia.
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