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Am J Psychiatry 1997; 154:867-869
Copyright © 1997 by American Psychiatric Association
Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
BD Greenberg, MS George, JD Martin, J Benjamin, TE Schlaepfer, M Altemus, EM Wassermann, RM Post and DL Murphy
Laboratory of Clinical Science, NIMH, Bethesda, MD 20892-1264, USA. bdg@helix.nih.gov
OBJECTIVE: Prefrontal mechanisms are implicated in obsessive-compulsive
disorder. The authors investigated whether prefrontal repetitive
transcranial magnetic stimulation influenced obsessive-compulsive disorder
symptoms. METHOD: Twelve patients with obsessive-compulsive disorder were
given repetitive transcranial magnetic stimulation (80% motor threshold, 20
Hz/2 seconds per minute for 20 minutes) to a right lateral prefrontal, a
left lateral prefrontal, and a midoccipital (control) site on separate
days, randomized. The patients' symptoms and mood were rated for 8 hours
afterward. RESULTS: Compulsive urges decreased significantly for 8 hours
after right lateral prefrontal repetitive transcranial magnetic
stimulation, but there were nonsignificant increases in compulsive urges
after repetitive transcranial magnetic stimulation of the midoccipital
site. A shorter- lasting (30 minutes), modest, and nonsignificant reduction
in compulsive urges occurred after left lateral prefrontal repetitive
transcranial magnetic stimulation. Mood improved during and 30 minutes
after right lateral prefrontal stimulation. CONCLUSIONS: These preliminary
results suggest that right prefrontal repetitive transcranial magnetic
stimulation might affect prefrontal mechanisms involved in
obsessive-compulsive disorder.
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