|
| | |
|
Am J Psychiatry 1997; 154:812-818
Copyright © 1997 by American Psychiatric Association
Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia
DW Zaidel, MM Esiri and PJ Harrison
Department of Psychology, University of California at Los Angeles 90095- 1563, USA.
OBJECTIVE: Schizophrenia may involve the two cerebral hemispheres
differentially. This study was conducted to determine whether left and
right hippocampal neuronal size, shape, and orientation are normally
asymmetrical or asymmetrically affected in schizophrenia. METHOD: The
authors examined postmortem tissue from the left and right hippocampus of
17 normal individuals and 14 individuals with schizophrenia. They measured
the size, shape, and variability in orientation of pyramidal neurons in
hippocampal subfields CA1-CA4 and the subiculum in computer images of
10-micron coronal sections stained with cresyl violet. RESULTS: Both
neuronal size and shape showed significant effects of diagnosis and a
three-way interaction between diagnosis, hemisphere, and subfield. Neurons
of the schizophrenic subjects were smaller than those of the normal
subjects in the left CA1, left CA2, and right CA3 subfields; their shape
differed from that of the normal subjects in the left CA1, left subiculum,
and right CA3 subfields. There were no group differences in variability of
neuronal orientation, but neurons in the CA3 genu in the schizophrenic
subjects were less variable on the right than on the left. In the normal
subjects, except for larger neurons in the left than in the right CA2
subfield and some left-right differences in variability of neuronal
orientation, no statistically significant asymmetries were observed.
CONCLUSIONS: The data confirm that hippocampal neuronal size is decreased
in schizophrenia and reveal that the shape of neurons is altered,
supporting the view that hippocampal cytoarchitectural abnormalities may be
part of the cerebral substrate of schizophrenia. They also provide further
evidence that the abnormalities are localized and lateralized.
This article has been cited by other articles:
|
|
|
|
 
J. R. HIGHLEY, M. A. WALKER, B. McDONALD, T. J. CROW, and M. M. ESIRI
Size of hippocampal pyramidal neurons in schizophrenia
The British Journal of Psychiatry,
November 1, 2003;
183(5):
414 - 417.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. ARNOLD
Cellular and Molecular Neuropathology of the Parahippocampal Region in Schizophrenia
Ann. N.Y. Acad. Sci.,
June 1, 2000;
911(1):
275 - 292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Rosoklija, G. Toomayan, S. P. Ellis, J. Keilp, J. J. Mann, N. Latov, A. P. Hays, and A. J. Dwork
Structural Abnormalities of Subicular Dendrites in Subjects With Schizophrenia and Mood Disorders: Preliminary Findings
Arch Gen Psychiatry,
April 1, 2000;
57(4):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Narr, P. M. Thompson, T. Sharma, J. Moussai, A. F. Cannestra, and A. W. Toga
Mapping Morphology of the Corpus Callosum in Schizophrenia
Cereb Cortex,
January 1, 2000;
10(1):
40 - 49.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Harrison
The neuropathology of schizophrenia: A critical review of the data and their interpretation
Brain,
April 1, 1999;
122(4):
593 - 624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Csernansky, S. Joshi, L. Wang, J. W. Haller, M. Gado, J. P. Miller, U. Grenander, and M. I. Miller
Hippocampal morphometry in schizophrenia by high dimensional brain mapping
PNAS,
September 15, 1998;
95(19):
11406 - 11411.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
