|
| | |
|
Am J Psychiatry 1997; 154:805-811
Copyright © 1997 by American Psychiatric Association
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers
A Breier, AK Malhotra, DA Pinals, NI Weisenfeld and D Pickar
Experimental Therapeutics Branch, NIMH, Bethesda, MD 20892, USA.
OBJECTIVE: Agents that antagonize the N-methyl-D-aspartic acid (NMDA)
receptor, such as phencyclidine and ketamine, produce an acute psychotic
state in normal individuals that resembles some symptoms of schizophrenia.
The aim of this study was to determine which brain regions are involved in
NMDA receptor-mediated psychosis. METHOD: Positron emission tomography with
[18F]fluorodeoxyglucose was used to determine cerebral metabolic activity
in 17 healthy volunteers while an acute psychotic state was induced
simultaneously by the administration of subanesthetic doses of ketamine.
RESULTS: Ketamine produced focal increases in metabolic activity in the
prefrontal cortex and an acute psychotic state. A change in one psychotic
symptom, conceptual disorganization, was significantly related to
prefrontal activation. CONCLUSIONS: These data suggest that the prefrontal
cortex may be involved in mediating NMDA receptor-induced psychosis.
This article has been cited by other articles:
|
|
|
|
 
J. F. W. Deakin, J. Lees, S. McKie, J. E. C. Hallak, S. R. Williams, and S. M. Dursun
Glutamate and the Neural Basis of the Subjective Effects of Ketamine: A Pharmaco-Magnetic Resonance Imaging Study
Arch Gen Psychiatry,
February 1, 2008;
65(2):
154 - 164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Homayoun and B. Moghaddam
NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons
J. Neurosci.,
October 24, 2007;
27(43):
11496 - 11500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Kargieman, N. Santana, G. Mengod, P. Celada, and F. Artigas
Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine
PNAS,
September 11, 2007;
104(37):
14843 - 14848.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Gallinat, T. Gotz, P. Kalus, M. Bajbouj, T. Sander, and G. Winterer
Genetic Variations of the NR3A Subunit of the NMDA Receptor Modulate Prefrontal Cerebral Activity in Humans.
J. Cogn. Neurosci.,
January 1, 2007;
19(1):
59 - 68.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Corlett, G. D. Honey, M. R. F. Aitken, A. Dickinson, D. R. Shanks, A. R. Absalom, M. Lee, E. Pomarol-Clotet, G. K. Murray, P. J. McKenna, et al.
Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis.
Arch Gen Psychiatry,
June 1, 2006;
63(6):
611 - 621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Narendran, W. G. Frankle, R. Keefe, R. Gil, D. Martinez, M. Slifstein, L. S. Kegeles, P. S. Talbot, Y. Huang, D.-R. Hwang, et al.
Altered Prefrontal Dopaminergic Function in Chronic Recreational Ketamine Users
Am J Psychiatry,
December 1, 2005;
162(12):
2352 - 2359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.D. Honey, R.A.E. Honey, C. O'Loughlin, S.R. Sharar, D. Kumaran, J. Suckling, D.K. Menon, C. Sleator, E.T. Bullmore, and P.C. Fletcher
Ketamine Disrupts Frontal and Hippocampal Contribution to Encoding and Retrieval of Episodic Memory: An fMRI Study
Cereb Cortex,
June 1, 2005;
15(6):
749 - 759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Homayoun, M. E. Jackson, and B. Moghaddam
Activation of Metabotropic Glutamate 2/3 Receptors Reverses the Effects of NMDA Receptor Hypofunction on Prefrontal Cortex Unit Activity in Awake Rats
J Neurophysiol,
April 1, 2005;
93(4):
1989 - 2001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lees, J. E.C. Hallak, J. F.W. Deakin, and S. M. Dursun
Gender Differences and the Effects of Ketamine in Healthy Volunteers
J Psychopharmacol,
September 1, 2004;
18(3):
337 - 339.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. E. Jackson, H. Homayoun, and B. Moghaddam
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
PNAS,
June 1, 2004;
101(22):
8467 - 8472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Avila, M. A. Weiler, A. C. Lahti, C. A. Tamminga, and G. K. Thaker
Effects of Ketamine on Leading Saccades During Smooth-Pursuit Eye Movements May Implicate Cerebellar Dysfunction in Schizophrenia
Am J Psychiatry,
September 1, 2002;
159(9):
1490 - 1496.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Albert, H. C. Hemmings Jr, A. I. B. Adamo, S. G. Potkin, S. Akbarian, C. A. Sandman, C. W. Cotman, W. E. Bunney Jr, and P. Greengard
Evidence for Decreased DARPP-32 in the Prefrontal Cortex of Patients With Schizophrenia
Arch Gen Psychiatry,
August 1, 2002;
59(8):
705 - 712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Goff and J. T. Coyle
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia
Am J Psychiatry,
September 1, 2001;
158(9):
1367 - 1377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Umbricht, L. Schmid, R. Koller, F. X. Vollenweider, D. Hell, and D. C. Javitt
Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers: Implications for Models of Cognitive Deficits in Schizophrenia
Arch Gen Psychiatry,
December 1, 2000;
57(12):
1139 - 1147.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
