Am J Psychiatry 1997; 154:682-684
Copyright © 1997 by American Psychiatric Association
Decreased anterior cingulate gyrus metabolic rate in schizophrenia
MM Haznedar, MS Buchsbaum, C Luu, EA Hazlett, BV Siegel Jr, J Lohr, J Wu, RJ Haier and WE Bunney Jr
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
OBJECTIVE: This study examined glucose metabolism in the anterior and
posterior cingulate cortex in schizophrenia. METHOD: Fifty unmedicated male
schizophrenic patients and 24 normal men were studied with positron
emission tomography. RESULTS: Compared with the normal men, the
schizophrenic patients had lower relative metabolic rates in the anterior
cingulate and higher rates in the posterior cingulate. CONCLUSIONS: The
findings suggest hypofunction in the anterior cingulate cortex in
schizophrenia.
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