|
| | |
|
Am J Psychiatry 1997; 154:551-553
Copyright © 1997 by American Psychiatric Association
Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study
RJ Baldessarini, L Tondo, G Floris and N Rudas
International Consortium for Bipolar Disorder Research, MA, USA. rjb@mrc309.mclean.org
OBJECTIVE: The aim of this study was to verify reduction of early affective
morbidity by gradual, rather than rapid, discontinuation of lithium
treatment. METHOD: For 78 patients with bipolar disorders, lithium
treatment was discontinued either rapidly (over 1-14 days) or gradually
(over 15-30 days). The effects of the two schedules were compared by
survival analysis of time to first recurrence. RESULTS: Median time to
recurrence was 5.6 times as long for gradual discontinuation (14.0 months)
as for rapid discontinuation (2.5 months). The ratios of the median
survival times for gradual and rapid discontinuation were similar in I and
II subtypes and in depression and mania (4-6:1). The polarities of the
episodes at onset and at first recurrence after lithium discontinuation
were 83.6% concordant. CONCLUSIONS: These results independently confirm a
reduction in morbid risk from slow discontinuation of lithium treatment for
bipolar disorders.
This article has been cited by other articles:
|
|
|
|
 
A. C. Viguera, T. Whitfield, R. J. Baldessarini, D. J. Newport, Z. Stowe, A. Reminick, A. Zurick, and L. S. Cohen
Risk of Recurrence in Women With Bipolar Disorder During Pregnancy: Prospective Study of Mood Stabilizer Discontinuation
Am J Psychiatry,
December 1, 2007;
164(12):
1817 - 1824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. H. Perlis, G. S. Sachs, B. Lafer, M. W. Otto, S. V. Faraone, J. M. Kane, and J. F. Rosenbaum
Effect of Abrupt Change From Standard to Low Serum Levels of Lithium: A Reanalysis of Double-Blind Lithium Maintenance Data
Am J Psychiatry,
July 1, 2002;
159(7):
1155 - 1159.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. BAUER, T. BSCHOR, D. KUNZ, A. BERGHOFER, A. STROHLE, and B. MULLER-OERLINGHAUSEN
Dr. Bauer and Colleagues Reply
Am J Psychiatry,
August 1, 2001;
158(8):
1338 - 1339.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. TONDO, R. J. BALDESSARINI, and G. FLORIS
Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders
The British Journal of Psychiatry,
June 1, 2001;
178
(41):
s184 - s190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I N. Ferrier
Developments in mood stabilisers: Depression and public health
Br. Med. Bull.,
March 1, 2001;
57(1):
179 - 192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Bowden, J. R. Calabrese, S. L. McElroy, L. Gyulai, A. Wassef, F. Petty, H. G. Pope Jr, J. C.-Y. Chou, P. E. Keck Jr, L. J. Rhodes, et al.
A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder
Arch Gen Psychiatry,
May 1, 2000;
57(5):
481 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Viguera, R. Nonacs, L. S. Cohen, L. Tondo, A. Murray, and R. J. Baldessarini
Risk of Recurrence of Bipolar Disorder in Pregnant and Nonpregnant Women After Discontinuing Lithium Maintenance
Am J Psychiatry,
February 1, 2000;
157(2):
179 - 184.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Armstrong and S. Dollow
Safety of patients participating in drug trials
BMJ,
September 19, 1998;
317(7161):
818 - 818.
[Full Text]
|
|
|
|
|
|
|
L. Tondo, R. J. Baldessarini, J. Hennen, and G. Floris
Lithium Maintenance Treatment of Depression and Mania in Bipolar I and Bipolar II Disorders
Am J Psychiatry,
May 1, 1998;
155(5):
638 - 645.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. J. Baldessarini, A. C. Viguera, W. T. Carpenter, N. R. Schooler, and J. M. Kane
Medication Removal and Research in Psychotic Disorders
Arch Gen Psychiatry,
March 1, 1998;
55(3):
281 - 283.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. K. Goodwin and S. N. Ghaemi
Understanding Manic-depressive Illness
Arch Gen Psychiatry,
January 1, 1998;
55(1):
23 - 25.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Moncrieff, R. J. Baldessarini, L. Tondo, and A. C. Viguera
Forty Years of Lithium Treatment
Arch Gen Psychiatry,
January 1, 1998;
55(1):
92 - 93.
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
