|
| | |
|
Am J Psychiatry 1997; 154:402-407
Copyright © 1997 by American Psychiatric Association
B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?
TK Murphy, WK Goodman, MW Fudge, RC Williams Jr, EM Ayoub, M Dalal, MH Lewis and JB Zabriskie
Department of Psychiatry, University of Florida College of Medicine, USA. TMurphy@college.med.ufl.edu
OBJECTIVE: It has been hypothesized that Sydenham's chorea, a major
manifestation of rheumatic fever, may provide a medical model for
obsessive-compulsive disorder and associated conditions, such as Tourette's
syndrome. Monoclonal antibody D8/17 identifies a B lymphocyte antigen with
expanded expression in nearly all patients with rheumatic fever and is
thought to be a trait marker for susceptibility to this complication of
group A streptococcal infection. The authors investigated whether D8/17
expression is greater than normal in some forms of obsessive-compulsive
disorder and Tourette's syndrome. METHOD: By immunofluorescence techniques,
31 patients with childhood-onset obsessive-compulsive disorder and/or
Tourette's syndrome or chronic tic disorder and 21 healthy comparison
subjects were evaluated for percentage of D8/17-positive B cells. None had
rheumatic fever or Sydenham's chorea. Levels of antineuronal antibodies and
streptococcal antibodies were also determined. RESULTS: The average
percentage of B cells expressing the D8/17 antigen was significantly higher
in the patients (mean = 22%, SD = 5%) than in the comparison subjects (mean
= 9%, SD = 2%). When classified categorically, all patients but only one
comparison subject were D8/17 positive. No difference between groups in the
presence of antineuronal antibodies or high streptococcal titers was found.
CONCLUSIONS: Patients with childhood-onset obsessive- compulsive disorder
or Tourette's syndrome had significantly greater B cell D8/17 expression
than comparison subjects despite the absence of documented Sydenham's
chorea or rheumatic fever. These findings suggest that D8/17 may serve as a
marker for susceptibility among some forms of childhood-onset
obsessive-compulsive disorder and Tourette's syndrome, as well as rheumatic
fever or Sydenham's chorea.
This article has been cited by other articles:
|
|
|
|
 
A. A. Mabrouk and V. Eapen
Challenges in the Identification and Treatment of PANDAS: A Case Series
J Trop Pediatr,
May 22, 2008;
(2008)
fmn039v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Pavone, E. Parano, R. Rizzo, and R. R. Trifiletti
Topical Review: Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Sydenham Chorea, PANDAS, and PANDAS Variants
J Child Neurol,
September 1, 2006;
21(9):
727 - 736.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. C. DALE, I. HEYMAN, G. GIOVANNONI, and A. W J. CHURCH
Incidence of anti-brain antibodies in children with obsessive-compulsive disorder
The British Journal of Psychiatry,
October 1, 2005;
187(4):
314 - 319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. K. Mell, R. L. Davis, and D. Owens
Association Between Streptococcal Infection and Obsessive-Compulsive Disorder, Tourette's Syndrome, and Tic Disorder
Pediatrics,
July 1, 2005;
116(1):
56 - 60.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Rippel, J. J. Hong, D. Y. Yoon, P. N. Williams, and H. S. Singer
Methodologic Factors Affect the Measurement of Anti-basal Ganglia Antibodies
Ann. Clin. Lab. Sci.,
April 1, 2005;
35(2):
121 - 130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Kim, J. E. Grant, S. I. Kim, T. A. Swanson, G. A. Bernstein, W. B. Jaszcz, K. A. Williams, and P. M. Schlievert
A Possible Association of Recurrent Streptococcal Infections and Acute Onset of Obsessive-Compulsive Disorder
J Neuropsychiatry Clin Neurosci,
August 1, 2004;
16(3):
252 - 260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Luo, J. F. Leckman, L. Katsovich, D. Findley, H. Grantz, D. M. Tucker, P. J. Lombroso, R. A. King, and D. E. Bessen
Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections
Pediatrics,
June 1, 2004;
113(6):
e578 - e585.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. L. Weisz, W. M. McMahon, J. C. Moore, N. H. Augustine, J. F. Bohnsack, J. F. Bale, M. B. Johnson, J. F. Morgan, J. Jensen, L. Y. Tani, et al.
D8/17 and CD19 Expression on Lymphocytes of Patients with Acute Rheumatic Fever and Tourette's Disorder
Clin. Vaccine Immunol.,
March 1, 2004;
11(2):
330 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. HAMILTON, M. A. GARVEY, and S. E. SWEDO
Sensitivity of the D8/17 Assay
Am J Psychiatry,
June 1, 2003;
160(6):
1193 - 1194.
[Full Text]
|
|
|
|
|
|
|
R.C. Dale
Autoimmunity and the basal ganglia: new insights into old diseases
QJM,
March 1, 2003;
96(3):
183 - 191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Murphy and M. E. Pichichero
Prospective Identification and Treatment of Children With Pediatric Autoimmune Neuropsychiatric Disorder Associated With Group A Streptococcal Infection (PANDAS)
Arch Pediatr Adolesc Med,
April 1, 2002;
156(4):
356 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Arnold and M. A. Richter
Is obsessive-compulsive disorder an autoimmune disease?
Can. Med. Assoc. J.,
November 1, 2001;
165(10):
1353 - 1358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jankovic
Tourette's Syndrome
N. Engl. J. Med.,
October 18, 2001;
345(16):
1184 - 1192.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Hoekstra, J. Bijzet, P. C. Limburg, M.-P. Steenhuis, P. W. Troost, M. D. Oosterhoff, J. Korf, C. G.M. Kallenberg, and R. B. Minderaa
Elevated D8/17 Expression on B Lymphocytes, a Marker of Rheumatic Fever, Measured With Flow Cytometry in Tic Disorder Patients
Am J Psychiatry,
April 1, 2001;
158(4):
605 - 610.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Stern, D. A. Silbersweig, K.-Y. Chee, A. Holmes, M. M. Robertson, M. Trimble, C. D. Frith, R. S. J. Frackowiak, and R. J. Dolan
A Functional Neuroanatomy of Tics in Tourette Syndrome
Arch Gen Psychiatry,
August 1, 2000;
57(8):
741 - 748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Cunningham
Pathogenesis of Group A Streptococcal Infections
Clin. Microbiol. Rev.,
July 1, 2000;
13(3):
470 - 511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Peterson, J. F. Leckman, D. Tucker, L. Scahill, L. Staib, H. Zhang, R. King, D. J. Cohen, J. C. Gore, and P. Lombroso
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Arch Gen Psychiatry,
April 1, 2000;
57(4):
364 - 372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Robertson
Tourette syndrome, associated conditions and the complexities of treatment
Brain,
March 1, 2000;
123(3):
425 - 462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-E. Dilenge, M. I. Shevell, and L. Dinh
Restricted Unilateral Sydenham's Chorea: Reversible Contralateral Striatal Hypermetabolism Demonstrated on Single Photon Emission Computed Tomographic Scanning
J Child Neurol,
August 1, 1999;
14(8):
509 - 513.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Hollander, G. DelGiudice-Asch, L. Simon, J. Schmeidler, C. Cartwright, C. M. DeCaria, J. Kwon, C. Cunningham-Rundles, F. Chapman, and J. B. Zabriskie
B Lymphocyte Antigen D8/17 and Repetitive Behaviors in Autism
Am J Psychiatry,
February 1, 1999;
156(2):
317 - 320.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Bartha, M. B. Stein, P. C. Williamson, D. J. Drost, R. W.J. Neufeld, T. J. Carr, G. Canaran, M. Densmore, G. Anderson, and A. R. Siddiqui
A Short Echo 1H Spectroscopy and Volumetric MRI Study of the Corpus Striatum in Patients With Obsessive- Compulsive Disorder and Comparison Subjects
Am J Psychiatry,
November 1, 1998;
155(11):
1584 - 1591.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. D. GREENBERG, D. L. MURPHY, and S. E. SWEDO
Symptom Exacerbation of Vocal Tics and Other Symptoms Associated With Streptococcal Pharyngitis in a Patient With Obsessive-Compulsive Disorder and Tics
Am J Psychiatry,
October 1, 1998;
155(10):
1459 - 1460.
[Full Text]
|
|
|
|
|
|
|
F. R. Asbahr, A. B. Negrão, V. Gentil, D. M.T. Zanetta, J. A. da Paz, M. J. Marques-Dias, and M. H. Kiss
Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study
Am J Psychiatry,
August 1, 1998;
155(8):
1122 - 1124.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A Marker for Childhood-Onset OCD?
Journal Watch Psychiatry,
May 1, 1997;
1997(501):
2 - 2.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
