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Am J Psychiatry 1997; 154:384-389
Copyright © 1997 by American Psychiatric Association
Emotional activation of limbic circuitry in elderly normal subjects in a PET study
S Paradiso, RG Robinson, NC Andreasen, JE Downhill, RJ Davidson, PT Kirchner, GL Watkins, LL Ponto and RD Hichwa
University of Iowa Hospitals and Clinics, Department of Psychiatry Administration, Iowa City 52242, USA.
OBJECTIVE: This study was undertaken to identify brain structures
associated with emotion in normal elderly subjects. METHOD: Eight normal
subjects aged 55-78 years were shown film clips intended to provoke the
emotions of happiness, fear, or disgust as well as a neutral state. During
emotional activation, regional cerebral blood flow was measured with the
use of [15O]H2O positron emission tomography imaging, and subjective
emotional responses were recorded. Data were analyzed by subtracting the
values during the neutral condition from the values in the various
emotional activations. RESULTS: The stimuli produced a general activation
in visual pathways that included the primary and secondary visual cortex,
involving regions associated with object and spatial recognition. In
addition, the specific emotions produced different regional limbic
activations, which suggests that different pathways may be used for
different types of emotional stimuli. CONCLUSIONS: Emotional activation in
normal elderly subjects was associated with increases in blood flow in
limbic and paralimbic brain structures. Brain activation may be specific to
the emotion being elicited but probably involves complex sensory,
association, and memory circuitry. Further studies are needed to identify
activations that are specific for emotion.
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