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Am J Psychiatry 1997; 154:239-242
Copyright © 1997 by American Psychiatric Association
Dopamine reuptake site densities in patients with social phobia
J Tiihonen, J Kuikka, K Bergstrom, U Lepola, H Koponen and E Leinonen
Department of Forensic Psychiatry, University of Kuopio, Finland.
OBJECTIVE: It has been suggested that social phobia is associated with
dysfunction of the noradrenergic and dopaminergic systems, but there are no
published anatomic data on the monoaminergic abnormalities found in the
brains of phobic patients. The authors studied the density of dopamine
reuptake sites in patients with social phobia. METHOD: The study included
11 patients with social phobia and 28 healthy comparison subjects, 11 of
whom were age- and gender-matched to the patients for the analyses.
Measurement of the density of dopamine reuptake sites was performed by
using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon
emission computed tomography (SPECT). RESULTS: Blind quantitative analysis
revealed that striatal dopamine reuptake site densities were markedly lower
in the patients with social phobia than in the age- and gender-matched
comparison subjects. CONCLUSIONS: The results indicate that social phobia
may be associated with a dysfunction of the striatal dopaminergic system.
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