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Am J Psychiatry 1997; 154:1451-1453
Copyright © 1997 by American Psychiatric Association
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients
JJ Mann, KM Malone, DA Nielsen, D Goldman, J Erdos and J Gelernter
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, USA.
OBJECTIVE: This study was designed to test the hypothesis that
serotonin-system-related genes may be correlated with suicide risk. METHOD:
Fifty-one unrelated Caucasian inpatients with major depression, with or
without a history of suicidal acts, were genotyped for a biallelic
polymorphism at the tryptophan hydroxylase locus. RESULTS: The less common
tryptophan hydroxylase U allele occurred with greater frequency in the
patients who had attempted suicide. A logistic regression analysis
confirmed an association between tryptophan hydroxylase genotype and
lifetime history of suicide attempts. CONCLUSIONS:
Serotonergic-system-related genes may influence the risk of suicide in
persons with major depression.
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