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Am J Psychiatry 1997; 154:1376-1383
Copyright © 1997 by American Psychiatric Association
Depression in medically ill hospitalized older adults: prevalence, characteristics, and course of symptoms according to six diagnostic schemes
HG Koenig, LK George, BL Peterson and CF Pieper
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.
OBJECTIVE: The purpose of this study was to examine and compare rates of
depression, correlates, and course of symptoms in medically ill
hospitalized elders through use of six diagnostic schemes (inclusive,
etiologic, exclusive-inclusive, exclusive-etiologic, substitutive-
inclusive, and substitutive-etiologic). METHOD: A consecutive series of 460
cognitively unimpaired patients aged 60 or over who were admitted to the
medical inpatient services of Duke Hospital underwent a structured
psychiatric evaluation administered by a psychiatrist. Patients with
depression were contacted by telephone at 12-week intervals after discharge
to assess weekly change in depressive symptoms (median follow-up time = 47
weeks). RESULTS: The prevalence of major depression varied from 10% to 21%
depending on diagnostic scheme; similarly, minor depression varied from 14%
to 25%. Diagnostic strategy made little difference in known psychological
and health characteristics of patients with depression (predictive
validity) or severity of depressive symptoms (convergent validity). The
diagnostic strategy that best distinguished a severe and persistent major
depression was the exclusive-etiologic approach; however, this strategy
missed 49% of patients with major depression identified by the inclusive
approach, almost 60% of whom continued to experience persistent symptoms of
depression many weeks after discharge. CONCLUSIONS: Diagnostic strategy
affects rates of major and minor depression, with about a twofold
difference between the extremes. There is little reason, however, to choose
one diagnostic scheme over another in all cases. Diagnostic strategy should
be chosen on the basis of the specific goals and purposes of the examiner.
While the exclusive- etiologic approach identifies the most severe and
persistent depressions, the inclusive approach is the most sensitive and
reliable approach and is an intermediate predictor of persistent
depression.
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