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Am J Psychiatry 1997; 154:81-87
Copyright © 1997 by American Psychiatric Association
Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects
DT George, C Benkelfat, RR Rawlings, MJ Eckardt, MJ Phillips, DJ Nutt, D Wynne, DL Murphy and M Linnoila
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-1250, USA.
OBJECTIVE: The purpose of this study was to explore central serotonergic
functions in subgroups of alcoholics and in healthy comparison subjects.
METHOD: The mixed serotonin (5-HT) agonist/antagonist
m-chlorophenylpiperazine (m-CPP) was administered to male alcoholic
patients who were classified according to the criteria of von Knorring et
al. as type I alcoholics (late onset) (N = 16) or type II alcoholics (early
onset with antisocial traits) (N = 24) and to 22 healthy comparison
subjects. Psychological, physiological, and neuroendocrine measures were
obtained before and after the m-CPP infusion. RESULTS: m-CPP elicited
subtype-related differential effects among the alcoholics; the type I
alcoholics reported more anger and anxiety, and the type II alcoholics
reported increased euphoria and a greater likelihood of drinking. The
healthy comparison subjects exhibited a greater increase in plasma ACTH
response to the m-CPP infusion than the alcoholics regardless of subtype.
CONCLUSIONS: Differences in certain 5-HT receptor functions may explain
some of the clinical characteristics that differentiate the type II and
type I subgroups of alcoholic patients. Furthermore, alcoholics may have
reduced sensitivity of 5-HT2C receptors in comparison with healthy
subjects.
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