|
| | |
|
Am J Psychiatry 1997; 154:110-112
Copyright © 1997 by American Psychiatric Association
Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever
SE Swedo, HL Leonard, BB Mittleman, AJ Allen, JL Rapoport, SP Dow, ME Kanter, F Chapman and J Zabriskie
Section on Behavioral Pediatrics, Child Psychiatry Branch, NIMH, Bethesda, MD 20892-1381, USA.
OBJECTIVE: The authors' goal was to determine whether a trait marker of
rheumatic fever susceptibility (labeled D8/17) could identify children with
pediatric autoimmune neuropsychiatric disorders (obsessive- compulsive
disorder and tic disorders) associated with streptococcal infections
(PANDAS). METHOD: Blood samples obtained from 27 children with PANDAS, nine
children with Sydenham's chorea, and 24 healthy children were evaluated for
D8/17 reactivity. Individuals were defined as D8/17 positive if they had
12% or more D8/17+ cells. RESULTS: The frequency of D8/17-positive
individuals was significantly higher in both patient groups than it was
among the healthy volunteers: 85% of the children with PANDAS and 89% of
the children with Sydenham's chorea, compared with 17% of the healthy
children, were D8/17 positive. Further, the mean number of D8/17+ cells was
similar in the two patient groups and was significantly higher in these
groups than in the group of healthy children. CONCLUSIONS: These results
suggest that there may be a subgroup of D8/17-positive children who present
with clinical symptoms of obsessive-compulsive disorder and Tourette's
syndrome, rather than Sydenham's chorea, but who have similar
poststreptococcal autoimmunity.
This article has been cited by other articles:
|
|
|
|
 
R. Kurlan, D. Johnson, E. L. Kaplan, and and the Tourette Syndrome Study Group
Streptococcal Infection and Exacerbations of Childhood Tics and Obsessive-Compulsive Symptoms: A Prospective Blinded Cohort Study
Pediatrics,
June 1, 2008;
121(6):
1188 - 1197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Pavone, E. Parano, R. Rizzo, and R. R. Trifiletti
Topical Review: Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Sydenham Chorea, PANDAS, and PANDAS Variants
J Child Neurol,
September 1, 2006;
21(9):
727 - 736.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. R. Morris, K. G. Meighen, and C. J. McDougle
Acute Onset of Obsessive-Compulsive Disorder in an Adolescent With Acute Lymphoblastic Leukemia
Psychosomatics,
October 1, 2005;
46(5):
458 - 460.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. K. Mell, R. L. Davis, and D. Owens
Association Between Streptococcal Infection and Obsessive-Compulsive Disorder, Tourette's Syndrome, and Tic Disorder
Pediatrics,
July 1, 2005;
116(1):
56 - 60.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Kim, J. E. Grant, S. I. Kim, T. A. Swanson, G. A. Bernstein, W. B. Jaszcz, K. A. Williams, and P. M. Schlievert
A Possible Association of Recurrent Streptococcal Infections and Acute Onset of Obsessive-Compulsive Disorder
J Neuropsychiatry Clin Neurosci,
August 1, 2004;
16(3):
252 - 260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Swedo, H. L. Leonard, M. Garvey, B. Mittleman, A. J. Allen, S. Perlmutter, L. Lougee, S. Dow, J. Zamkoff, and B. K. Dubbert
Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases
Focus,
July 1, 2004;
2(3):
496 - 506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R C Dale, I Heyman, R A H Surtees, A J Church, G Giovannoni, R Goodman, and B G R Neville
Dyskinesias and associated psychiatric disorders following streptococcal infections
Arch. Dis. Child.,
July 1, 2004;
89(7):
604 - 610.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. SPESSOT, K. J. PLESSEN, and B. S. PETERSON
Neuroimaging of Developmental Psychopathologies: The Importance of Self-Regulatory and Neuroplastic Processes in Adolescence
Ann. N.Y. Acad. Sci.,
June 1, 2004;
1021(1):
86 - 104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Luo, J. F. Leckman, L. Katsovich, D. Findley, H. Grantz, D. M. Tucker, P. J. Lombroso, R. A. King, and D. E. Bessen
Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections
Pediatrics,
June 1, 2004;
113(6):
e578 - e585.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Chmelik, N. Awadallah, F. S. Hadi, K. Quinn, and K. Franco
Varied Presentation of Pandas: A Case Series
Clinical Pediatrics,
May 1, 2004;
43(4):
379 - 382.
[PDF]
|
|
|
|
|
|
|
R. Kurlan and E. L. Kaplan
The Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection (PANDAS) Etiology for Tics and Obsessive-Compulsive Symptoms: Hypothesis or Entity? Practical Considerations for the Clinician
Pediatrics,
April 1, 2004;
113(4):
883 - 886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Weisz, W. M. McMahon, J. C. Moore, N. H. Augustine, J. F. Bohnsack, J. F. Bale, M. B. Johnson, J. F. Morgan, J. Jensen, L. Y. Tani, et al.
D8/17 and CD19 Expression on Lymphocytes of Patients with Acute Rheumatic Fever and Tourette's Disorder
Clin. Vaccine Immunol.,
March 1, 2004;
11(2):
330 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Hoffman, M. Hornig, K. Yaddanapudi, O. Jabado, and W. I. Lipkin
A Murine Model for Neuropsychiatric Disorders Associated with Group A {beta}-Hemolytic Streptococcal Infection
J. Neurosci.,
February 18, 2004;
24(7):
1780 - 1791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Sweeten, S. L. Bowyer, D. J. Posey, G. M. Halberstadt, and C. J. McDougle
Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
Pediatrics,
November 1, 2003;
112(5):
e420 - 420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. HAMILTON, M. A. GARVEY, and S. E. SWEDO
Sensitivity of the D8/17 Assay
Am J Psychiatry,
June 1, 2003;
160(6):
1193 - 1194.
[Full Text]
|
|
|
|
|
|
|
R.C. Dale
Autoimmunity and the basal ganglia: new insights into old diseases
QJM,
March 1, 2003;
96(3):
183 - 191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Sanger
Pathophysiology of Pediatric Movement Disorders
J Child Neurol,
January 1, 2003;
18(1_suppl):
S9 - S24.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. S. Sokol, P. E. Ward, H. Tamiya, D. G. Kondo, D. Houston, and J. B. Zabriskie
D8/17 Expression on B Lymphocytes in Anorexia Nervosa
Am J Psychiatry,
August 1, 2002;
159(8):
1430 - 1432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Murphy and M. E. Pichichero
Prospective Identification and Treatment of Children With Pediatric Autoimmune Neuropsychiatric Disorder Associated With Group A Streptococcal Infection (PANDAS)
Arch Pediatr Adolesc Med,
April 1, 2002;
156(4):
356 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Arnold and M. A. Richter
Is obsessive-compulsive disorder an autoimmune disease?
Can. Med. Assoc. J.,
November 1, 2001;
165(10):
1353 - 1358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jankovic
Tourette's Syndrome
N. Engl. J. Med.,
October 18, 2001;
345(16):
1184 - 1192.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. C. Nelson, G. L. Hanna, J. J. Hudziak, K. N. Botteron, A. C. Heath, and R. D. Todd
Obsessive-Compulsive Scale of the Child Behavior Checklist: Specificity, Sensitivity, and Predictive Power
Pediatrics,
July 1, 2001;
108(1):
e14 - 14.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T B Babel, P C Warnke, and C B Ostertag
Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndrome
J. Neurol. Neurosurg. Psychiatry,
May 1, 2001;
70(5):
666 - 671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. E. Lyon and K. Midkiff
Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Overview and Nursing Implications
Journal of the American Psychiatric Nurses Association,
April 1, 2001;
7(2):
35 - 38.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Hoekstra, J. Bijzet, P. C. Limburg, M.-P. Steenhuis, P. W. Troost, M. D. Oosterhoff, J. Korf, C. G.M. Kallenberg, and R. B. Minderaa
Elevated D8/17 Expression on B Lymphocytes, a Marker of Rheumatic Fever, Measured With Flow Cytometry in Tic Disorder Patients
Am J Psychiatry,
April 1, 2001;
158(4):
605 - 610.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. W. Cunningham
Pathogenesis of Group A Streptococcal Infections
Clin. Microbiol. Rev.,
July 1, 2000;
13(3):
470 - 511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Weir
Treating obsessive-compulsive and tic disorders
Can. Med. Assoc. J.,
July 1, 2000;
163(1):
82 - 82.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Peterson, J. F. Leckman, D. Tucker, L. Scahill, L. Staib, H. Zhang, R. King, D. J. Cohen, J. C. Gore, and P. Lombroso
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Arch Gen Psychiatry,
April 1, 2000;
57(4):
364 - 372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Robertson
Tourette syndrome, associated conditions and the complexities of treatment
Brain,
March 1, 2000;
123(3):
425 - 462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-E. Dilenge, M. I. Shevell, and L. Dinh
Restricted Unilateral Sydenham's Chorea: Reversible Contralateral Striatal Hypermetabolism Demonstrated on Single Photon Emission Computed Tomographic Scanning
J Child Neurol,
August 1, 1999;
14(8):
509 - 513.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Hollander, G. DelGiudice-Asch, L. Simon, J. Schmeidler, C. Cartwright, C. M. DeCaria, J. Kwon, C. Cunningham-Rundles, F. Chapman, and J. B. Zabriskie
B Lymphocyte Antigen D8/17 and Repetitive Behaviors in Autism
Am J Psychiatry,
February 1, 1999;
156(2):
317 - 320.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Bartha, M. B. Stein, P. C. Williamson, D. J. Drost, R. W.J. Neufeld, T. J. Carr, G. Canaran, M. Densmore, G. Anderson, and A. R. Siddiqui
A Short Echo 1H Spectroscopy and Volumetric MRI Study of the Corpus Striatum in Patients With Obsessive- Compulsive Disorder and Comparison Subjects
Am J Psychiatry,
November 1, 1998;
155(11):
1584 - 1591.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. D. GREENBERG, D. L. MURPHY, and S. E. SWEDO
Symptom Exacerbation of Vocal Tics and Other Symptoms Associated With Streptococcal Pharyngitis in a Patient With Obsessive-Compulsive Disorder and Tics
Am J Psychiatry,
October 1, 1998;
155(10):
1459 - 1460.
[Full Text]
|
|
|
|
|
|
|
F. R. Asbahr, A. B. Negrão, V. Gentil, D. M.T. Zanetta, J. A. da Paz, M. J. Marques-Dias, and M. H. Kiss
Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study
Am J Psychiatry,
August 1, 1998;
155(8):
1122 - 1124.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. E. Swedo, H. L. Leonard, M. Garvey, B. Mittleman, A. J. Allen, S. Perlmutter, S. Dow, J. Zamkoff, B. K. Dubbert, and L. Lougee
Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases
Am J Psychiatry,
February 1, 1998;
155(2):
264 - 271.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.K. Conners
Is ADHD a disease?
J Atten Disord,
April 1, 1997;
2(1):
3 - 17.
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
