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Am J Psychiatry 1996; 153:1212-1215
Copyright © 1996 by American Psychiatric Association
MRI signal hyperintensities in geriatric depression
BS Greenwald, E Kramer-Ginsberg, RR Krishnan, M Ashtari, PM Aupperle and M Patel
Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA.
OBJECTIVE: The authors rated periventricular and subcortical signal
hyperintensities on magnetic resonance imaging (MRI) scans in elderly
patients with depression and in normal subjects with similar demographic
features to examine whether such changes discriminate patients with
depression from normal subjects and whether they are associated with any
clinical variables. METHOD: Two established hyperintensity rating systems
were used to compare the MRI brain scans of 48 elderly patients with
depression diagnosed according to DSM-III-R with the scans of 39 normal
elderly subjects. RESULTS: Elderly depressed patients manifested
significantly more severe hyperintensity ratings in the subcortical gray
matter than age-matched comparison subjects. Significant differences were
not identified between patients with similar current ages and
cerebrovascular disease risk who had early-onset or late-onset depression.
CONCLUSIONS: These findings support those of neuroimaging studies
implicating the basal ganglia in depression and geriatric depression. The
data suggest that the relationship observed in some reports between
late-onset depression and MRI hyperintensities is most likely a function of
cerebrovascular disease risk and age.
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