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Am J Psychiatry 1996; 153:1060-1064
Copyright © 1996 by American Psychiatric Association
Family history of panic disorder and hypersensitivity to CO2 in patients with panic disorder
G Perna, A Bertani, D Caldirola and L Bellodi
Department of Neuropsychiatric Sciences, San Raffaele Hospital, Milan, Italy.
OBJECTIVE: The authors investigated the relationships between
hypersensitivity to CO2 and familial-genetic risk for panic disorder in
patients with panic disorder. METHOD: Morbidity risks for panic disorder
were calculated for families of 203 patients with panic disorder, each of
whom was challenged with 35% CO2. RESULTS: Patients who reacted with a
positive response to the 35% CO2 challenge showed a genetic risk for panic
disorder (morbidity risk = 14.4%) that was significantly higher than that
for patients who did not react (morbidity risk = 3.9%). CONCLUSIONS: These
findings support the idea that hypersensitivity to CO2 might be associated
with a subtype of panic disorder specifically related to a greater familial
loading.
This article has been cited by other articles:
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