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Am J Psychiatry 1996; 153:945-947
Copyright © 1996 by American Psychiatric Association
Four-year outcome for cognitive behavioral treatment of residual symptoms in major depression
GA Fava, S Grandi, M Zielezny, C Rafanelli and R Canestrari
Department of Psychology, University of Bologna, Italy.
OBJECTIVE: The authors' goal was to determine whether cognitive behavioral
treatment of residual symptoms of depression might have a significant
effect on relapse rate. METHOD: In an earlier study, 40 patients with
primary major depressive disorder who had been successfully treated with
antidepressant drugs were randomly assigned to either cognitive behavioral
treatment of residual symptoms or standard clinical management. In both
types of treatment, antidepressant drugs were gradually tapered and
discontinued. In this study, a 4-year follow-up assessment was performed.
RESULTS: Cognitive behavioral treatment resulted in a substantially lower
relapse rate (35%) than did clinical management (70%). CONCLUSIONS:
Cognitive behavioral treatment of residual symptoms reduces the risk of
relapse in depressed patients, probably by affecting the progression of
residual symptoms to prodromes of relapse.
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