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Am J Psychiatry 1996; 153:721-724
Copyright © 1996 by American Psychiatric Association
Dynamic susceptibility contrast MRI of regional cerebral blood volume in Alzheimer's disease
GJ Harris, RF Lewis, A Satlin, CD English, TM Scott, DA Yurgelun-Todd and PF Renshaw
Department of Psychiatry, New England Medical Center, Boston, MA 02111, USA.
OBJECTIVE: The purpose of this study was to investigate the potential
effectiveness of dynamic susceptibility contrast magnetic resonance imaging
(MRI) to discriminate elderly patients with Alzheimer's disease from normal
matched comparison subjects. METHOD: Images of regional cerebral blood
volume (CBV) were generated from echo-planar MRI with the dynamic
susceptibility contrast method in 13 Alzheimer's disease patients and 13
comparison subjects group-matched on age and gender. RESULTS:
Temporoparietal cerebral blood volume, expressed as a percentage of the
cerebellum value, was reduced 17% bilaterally in the patients with
Alzheimer's disease. Blood volume in sensorimotor regions was reduced only
8.5% in the patients. Discriminant function analysis based on left and
right temporoparietal measures correctly classified 88.5% of the subjects
as patients or comparison subjects. Temporoparietal CBV was reduced even in
mildly affected Alzheimer's disease patients (Mini-Mental State scores >
24). CONCLUSIONS: Dynamic susceptibility contrast MRI of regional CBV is
promising as a nonradioactive, potentially lower-cost alternative to other
functional neuroimaging methods for evaluating Alzheimer's disease.
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