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Am J Psychiatry 1996; 153:477-482
Copyright © 1996 by American Psychiatric Association
Immunity in young adults with major depressive disorder
SJ Schleifer, SE Keller, JA Bartlett, HM Eckholdt and BR Delaney
Department of Psychiatry, UMDNJ-New Jersey Medical School, Newark, 07103, USA.
OBJECTIVE: The authors previously found evidence for an age-related
association between major depression and altered immunity. The present
study was designed to assess a range of immune measures in young adults
with major depression. METHOD: A homogeneous group of 21 unmedicated,
ambulatory young adults with unipolar major depressive episode, as
determined with the Structured Clinical Interview for DSM-III-R, were
assessed in comparison with 21 matched nondepressed subjects. An extended
battery of quantitative and functional immune measures was obtained on the
same day from depressed and nondepressed subjects. RESULTS: Young adult
subjects with major depression had more circulating leukocytes and
granulocytes, fewer CD56+ (natural killer [NK]) cells, and, when the number
of circulating NK cells was controlled, less NK cell activity. Mitogen
responses, consistent with the authors' previous report, showed little
difference between the young adults with and without major depression
except for a possibly greater response at the highest dose of
phytohemagglutinin. CONCLUSIONS: Major depression in young adults is
associated with alterations in aspects of the immune system primarily
involving NK cells. Some but not all these immune changes differ from those
found in older depressed adults.
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