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Am J Psychiatry 1996; 153:424-426
Copyright © 1996 by American Psychiatric Association
Negative symptoms in Alzheimer's disease
WE Reichman, AC Coyne, S Amirneni, B Molino Jr and S Egan
COPSA Institute for Alzheimer's Disease and Related Disorders, University of Medicine and Dentistry of New Jersey, Piscataway 08855- 1392, USA.
OBJECTIVE: This study was undertaken to demonstrate that negative symptoms
are prominent in patients with Alzheimer's disease and are distinct from
depression. METHOD: patients with Alzheimer's disease (N=24) and a group of
cognitively intact older adults (N=26) were compared in terms of scores on
the Scale for the Assessment of Negative Symptoms in Alzheimer's Disease.
RESULTS: Negative symptoms were more severe in patients with Alzheimer's
disease than in the healthy elderly comparison subjects. Among the patients
with Alzheimer's disease, negative symptoms were correlated with dementia
severity. CONCLUSIONS: Patients with Alzheimer's disease display little
interest in self-care, work and household tasks, social and family
activities, and emotional needs of others, despite an absence of depressive
symptoms, positive symptoms, comorbid systemic illnesses, or medication
exposure. Such negative symptoms may contribute to functional disability
and thus complicate management of such patients.
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