Am J Psychiatry 1996; 153:411-413
Copyright © 1996 by American Psychiatric Association

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Change in thyroid hormone levels following response to cognitive therapy for major depression

R Joffe, Z Segal and W Singer
Department of Psychiatry, McMaster University, Hamilton, Ont., Canada.

OBJECTIVE: Various somatic antidepressant treatments of depression are associated with substantial but limited decreases in T4 levels. This study examined changes in patients' thyroid hormone levels during a period of cognitive behavior therapy. METHOD: Thyroid hormone levels of 30 patients with major depressive disorder were measured before and after they received 20 weekly sessions of cognitive behavior therapy. RESULTS: There were significant decreases in measures of T4 in the 17 responders to cognitive behavior therapy and increases in the 13 nonresponders. CONCLUSIONS: Cognitive behavior therapy has an effect on the thyroid axis similar to that of somatic antidepressant treatments.

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