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Am J Psychiatry 1996; 153:281-283
Copyright © 1996 by American Psychiatric Association
Experience of a "slip" among alcoholics treated with naltrexone or placebo
SS O'Malley, AJ Jaffe, S Rode and BJ Rounsaville
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
OBJECTIVE: This study tested the hypothesis that naltrexone reduces relapse
rates among alcoholics by modifying the reinforcing effects of initial
alcohol consumption and alcohol-induced craving. METHOD: Sixteen alcoholic
patients treated with naltrexone and 27 treated with placebo who
participated in a 12-week clinical trial reported retrospectively on their
subjective responses to their first episode of a lapse into alcohol
consumption and on their reasons for terminating the drinking episode.
RESULTS: Compared to the subjects who received placebo, the subjects who
received naltrexone reported lower levels of craving for alcohol and were
more likely to give reasons for terminating drinking that were consistent
with decreased incentive to drink. CONCLUSIONS: These findings support the
hypothesis that a central effect of naltrexone is the modification of
alcohol-induced craving.
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