|
| | |
|
Am J Psychiatry 1996; 153:268-270
Copyright © 1996 by American Psychiatric Association
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity
JK Daniels, NM Williams, J Williams, LA Jones, AG Cardno, KC Murphy, G Spurlock, B Riley, P Scambler, P Asherson, P McGuffin and MJ Owen
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines
by methylating their m-hydroxy group. Some previous studies using
biochemical methods have found higher levels of COMT activity in
schizophrenic patients. Recently, the genetic polymorphism that underlies
variation in COMT activity, which results in the creation of a NlaIII
restriction site in the low-activity allele, has been elucidated. METHOD:
This study investigated this polymorphism in 78 unrelated schizophrenic
patients and 78 comparison subjects matched for age and ethnicity.
High-molecular-weight DNA was isolated from lymphocytes with routine
procedures, and each individual was typed for high and low COMT activity.
RESULTS: The frequency of the NlaIII polymorphism was 0.51 in the
schizophrenic patients and 0.53 in the comparison subjects, and no
significant allelic or genotypic associations were observed. CONCLUSIONS:
There was no evidence for variation in COMT activity between a group of
schizophrenic patients and matched comparison subjects.
This article has been cited by other articles:
|
|
|
|
 
S. J. Bishop, J. Fossella, C. J. Croucher, and J. Duncan
COMT val158met Genotype Affects Recruitment of Neural Mechanisms Supporting Fluid Intelligence
Cereb Cortex,
September 1, 2008;
18(9):
2132 - 2140.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Haraldsson, U. Ettinger, B. B. Magnusdottir, T. Sigmundsson, E. Sigurdsson, A. Ingason, and H. Petursson
Catechol-O-Methyltransferase Val158Met Polymorphism and Antisaccade Eye Movements in Schizophrenia
Schizophr Bull,
June 17, 2008;
(2008)
sbn064v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Williams, M. J. Owen, and M. C. O'Donovan
Is COMT a Susceptibility Gene for Schizophrenia?
Schizophr Bull,
May 1, 2007;
33(3):
635 - 641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ohnishi, R. Hashimoto, T. Mori, K. Nemoto, Y. Moriguchi, H. Iida, H. Noguchi, T. Nakabayashi, H. Hori, M. Ohmori, et al.
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia
Brain,
February 1, 2006;
129(2):
399 - 410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rosa, V. Peralta, M. J. Cuesta, A. Zarzuela, F. Serrano, A. Martinez-Larrea, and L. Fananas
New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis
Am J Psychiatry,
June 1, 2004;
161(6):
1110 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Diamond, L. Briand, J. Fossella, and L. Gehlbach
Genetic and Neurochemical Modulation of Prefrontal Cognitive Functions in Children
Am J Psychiatry,
January 1, 2004;
161(1):
125 - 132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. O'Donovan, N. M. Williams, and M. J. Owen
Recent advances in the genetics of schizophrenia
Hum. Mol. Genet.,
October 15, 2003;
12(90002):
R125 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Glatt, S. V. Faraone, and M. T. Tsuang
Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies
Am J Psychiatry,
March 1, 2003;
160(3):
469 - 476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-M. Woo, K.-S. Yoon, and B.-H. Yu
Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder
Am J Psychiatry,
October 1, 2002;
159(10):
1785 - 1787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Egan, T. E. Goldberg, B. S. Kolachana, J. H. Callicott, C. M. Mazzanti, R. E. Straub, D. Goldman, and D. R. Weinberger
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
PNAS,
May 24, 2001;
(2001)
111134598.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. T. Mannisto and S. Kaakkola
Catechol-O-methyltransferase (COMT): Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors
Pharmacol. Rev.,
December 1, 1999;
51(4):
593 - 628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Murphy, L. A. Jones, and M. J. Owen
High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome
Arch Gen Psychiatry,
October 1, 1999;
56(10):
940 - 945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-H. Chen, Y.-R. Lee, M.-Y. Chung, F.-C. Wei, F.-J. Koong, C.-K. Shaw, J.-I Yeh, and K.-J. Hsiao
Systematic Mutation Analysis of the Catechol O-Methyltransferase Gene as a Candidate Gene for Schizophrenia
Am J Psychiatry,
August 1, 1999;
156(8):
1273 - 1275.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Karayiorgou, M. Altemus, B. L. Galke, D. Goldman, D. L. Murphy, J. Ott, and J. A. Gogos
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder
PNAS,
April 29, 1997;
94(9):
4572 - 4575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Egan, T. E. Goldberg, B. S. Kolachana, J. H. Callicott, C. M. Mazzanti, R. E. Straub, D. Goldman, and D. R. Weinberger
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
PNAS,
June 5, 2001;
98(12):
6917 - 6922.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1996
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
