PET and MRI of the thalamus in never-medicated patients with schizophrenia



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by Buchsbaum, M. S.
	Articles by Bunney, W. E.
	Search for Related Content



	PubMed Citation
	Articles by Buchsbaum, M. S.
	Articles by Bunney, W. E., Jr



	Neurophysiology
	Schizophrenia Spectrum Disorders
	MRI
	PET
	Neurodevelopment

Am J Psychiatry 1996; 153:191-199
Copyright © 1996 by American Psychiatric Association

REGULAR ARTICLES

PET and MRI of the thalamus in never-medicated patients with schizophrenia

MS Buchsbaum, T Someya, CY Teng, L Abel, S Chin, A Najafi, RJ Haier, J Wu and WE Bunney Jr
Neuroscience PET Center, Mt. Sinai School of Medicine, New York, NY 10029-6574, USA.

OBJECTIVE: This study reports the first paired measurements of glucose metabolism and size of thalamic regions in never-medicated schizophrenic patients using coregistered magnetic resonance imaging (MRI) templates. METHOD: Positron emission tomography with [18F]fluorodeoxyglucose and matching MRI scans were obtained in 20 never-medicated patients with schizophrenia and 15 normal volunteers. Methods for thalamic edge finding, statistical testing of shape differences with chi-square maps, and MRI localization of major thalamic subregions were developed. RESULTS: Patients with schizophrenia showed a diminished metabolic rate in the right thalamus, with a loss of the normal pattern of right greater than left asymmetry. Division into anterior/posterior segments revealed that the left anterior and right posterior showed the decrease. Differences were greater for metabolism in the weighted thalamic area (ratexarea) than for rate per unit area, a finding consistent with reported greater decreases in total neuron number than of neuron density in the thalami of schizophrenic patients. The area of the thalamus was smaller in the patients than in the volunteers, and this difference was greatest in the left anterior region. CONCLUSIONS: The reduced thalamic activity observed in this study lends further support to the concept of deficits in sensory filtering in schizophrenia.

This article has been cited by other articles:

A. M. Brickman, M. S. Buchsbaum, Z. Ivanov, J. C. Borod, N. S. Foldi, E. Hahn, S. A. Mitelman, E. A. Hazlett, S. J. Lincoln, R. E. Newmark, et al.
Internal Capsule Size in Good-Outcome and Poor-Outcome Schizophrenia
J Neuropsychiatry Clin Neurosci, August 1, 2006; 18(3): 364 - 376.
[Abstract] [Full Text] [PDF]

S. Cervenka, S. E. Palhagen, R. A. Comley, G. Panagiotidis, Z. Cselenyi, J. C. Matthews, R. Y. Lai, C. Halldin, and L. Farde
Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
Brain, August 1, 2006; 129(8): 2017 - 2028.
[Abstract] [Full Text] [PDF]

T. Egner and J. Hirsch
Where Memory Meets Attention: Neural Substrates of Negative Priming
J. Cogn. Neurosci., November 1, 2005; 17(11): 1774 - 1784.
[Abstract] [Full Text] [PDF]

S. M. Clinton, H. M. Ibrahim, K. A. Frey, K. L. Davis, V. Haroutunian, and J. H. Meador-Woodruff
Dopaminergic Abnormalities in Select Thalamic Nuclei in Schizophrenia: Involvement of the Intracellular Signal Integrating Proteins Calcyon and Spinophilin
Am J Psychiatry, October 1, 2005; 162(10): 1859 - 1871.
[Abstract] [Full Text] [PDF]

M. A. Sanchez-Gonzalez, M. A. Garcia-Cabezas, B. Rico, and C. Cavada
The Primate Thalamus Is a Key Target for Brain Dopamine
J. Neurosci., June 29, 2005; 25(26): 6076 - 6083.
[Abstract] [Full Text] [PDF]

D. S. Lehrer, B. T. Christian, J. Mantil, A. C. Murray, B. R. Buchsbaum, T. R. Oakes, W. Byne, E. M. Kemether, and M. S. Buchsbaum
Thalamic and Prefrontal FDG Uptake in Never Medicated Patients With Schizophrenia
Am J Psychiatry, May 1, 2005; 162(5): 931 - 938.
[Abstract] [Full Text] [PDF]

A. J. Fabiano, M. A. Horsfield, and R. Bakshi
Interhemispheric Asymmetry of Brain Diffusivity in Normal Individuals: A Diffusion-Weighted MR Imaging Study
AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1089 - 1094.
[Abstract] [Full Text] [PDF]

F. Yasuno, T. Suhara, Y. Okubo, Y. Sudo, M. Inoue, T. Ichimiya, A. Takano, K. Nakayama, C. Halldin, and L. Farde
Low Dopamine D2 Receptor Binding in Subregions of the Thalamus in Schizophrenia
Am J Psychiatry, June 1, 2004; 161(6): 1016 - 1022.
[Abstract] [Full Text] [PDF]

J. G. Csernansky, M. K. Schindler, N. R. Splinter, L. Wang, M. Gado, L. D. Selemon, D. Rastogi-Cruz, J. A. Posener, P. A. Thompson, and M. I. Miller
Abnormalities of Thalamic Volume and Shape in Schizophrenia
Am J Psychiatry, May 1, 2004; 161(5): 896 - 902.
[Abstract] [Full Text] [PDF]

E. A. Hazlett, M. S. Buchsbaum, E. Kemether, R. Bloom, J. Platholi, A. M. Brickman, L. Shihabuddin, C. Tang, and W. Byne
Abnormal Glucose Metabolism in the Mediodorsal Nucleus of the Thalamus in Schizophrenia
Am J Psychiatry, February 1, 2004; 161(2): 305 - 314.
[Abstract] [Full Text] [PDF]

J. H. MEADOR-WOODRUFF, S. M. CLINTON, M. BENEYTO, and R. E. McCULLUMSMITH
Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia
Ann. N.Y. Acad. Sci., November 1, 2003; 1003(1): 75 - 93.
[Abstract] [Full Text] [PDF]

E. M. Kemether, M. S. Buchsbaum, W. Byne, E. A. Hazlett, M. Haznedar, A. M. Brickman, J. Platholi, and R. Bloom
Magnetic Resonance Imaging of Mediodorsal, Pulvinar, and Centromedian Nuclei of the Thalamus in Patients With Schizophrenia
Arch Gen Psychiatry, October 1, 2003; 60(10): 983 - 991.
[Abstract] [Full Text] [PDF]

S. M. Clinton, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
Altered Transcript Expression of NMDA Receptor-Associated Postsynaptic Proteins in the Thalamus of Subjects With Schizophrenia
Am J Psychiatry, June 1, 2003; 160(6): 1100 - 1109.
[Abstract] [Full Text] [PDF]

E. V. Sullivan, M. J. Rosenbloom, K. L. Serventi, A. Deshmukh, and A. Pfefferbaum
Effects of Alcohol Dependence Comorbidity and Antipsychotic Medication on Volumes of the Thalamus and Pons in Schizophrenia
Am J Psychiatry, June 1, 2003; 160(6): 1110 - 1116.
[Abstract] [Full Text] [PDF]

S. Miyamoto, A. S. LaMantia, G. E. Duncan, P. Sullivan, J. H. Gilmore, and J. A. Lieberman
Recent Advances in the Neurobiology of Schizophrenia
Mol. Interv., February 1, 2003; 3(1): 27 - 39.
[Abstract] [Full Text] [PDF]

M. S. Bagary, J. Foong, M. Maier, G. duBoulay, G. J. Barker, D. H. Miller, and M. A. Ron
A Magnetization Transfer Analysis of the Thalamus in Schizophrenia
J Neuropsychiatry Clin Neurosci, November 1, 2002; 14(4): 443 - 448.
[Abstract] [Full Text] [PDF]

H. Ananth, I. Popescu, H. D. Critchley, C. D. Good, R. S.J. Frackowiak, and R. J. Dolan
Cortical and Subcortical Gray Matter Abnormalities in Schizophrenia Determined Through Structural Magnetic Resonance Imaging With Optimized Volumetric Voxel-Based Morphometry
Am J Psychiatry, September 1, 2002; 159(9): 1497 - 1505.
[Abstract] [Full Text] [PDF]

W. CAHN, H. E. H. POL, M. BONGERS, H. G. SCHNACK, R. C. W. MANDL, N. E. M. VAN HAREN, S. DURSTON, H. KONING, J. A. VAN DER LINDEN, and R. S. KAHN
Brain morphology in antipsychotic-naive schizophrenia: a study of multiple brain structures
The British Journal of Psychiatry, September 1, 2002; 181 (43): s66 - s72.
[Abstract] [Full Text] [PDF]

D. F. Braus, W. Weber-Fahr, H. Tost, M. Ruf, and F. A. Henn
Sensory Information Processing in Neuroleptic-Naive First-Episode Schizophrenic Patients: A Functional Magnetic Resonance Imaging Study
Arch Gen Psychiatry, August 1, 2002; 59(8): 696 - 701.
[Abstract] [Full Text] [PDF]

R. E. Smith, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
Expression of Excitatory Amino Acid Transporter Transcripts in the Thalamus of Subjects With Schizophrenia
Am J Psychiatry, September 1, 2001; 158(9): 1393 - 1399.
[Abstract] [Full Text] [PDF]

D. A. Lewis, D. A. Cruz, D. S. Melchitzky, and J. N. Pierri
Lamina-Specific Deficits in Parvalbumin-Immunoreactive Varicosities in the Prefrontal Cortex of Subjects With Schizophrenia: Evidence for Fewer Projections From the Thalamus
Am J Psychiatry, September 1, 2001; 158(9): 1411 - 1422.
[Abstract] [Full Text] [PDF]

D. R. Rosenberg, A. Amponsah, A. Sullivan, S. MacMillan, and G. J. Moore
Increased Medial Thalamic Choline in Pediatric Obsessive-Compulsive Disorder as Detected by Quantitative in Vivo Spectroscopic Imaging
J Child Neurol, September 1, 2001; 16(9): 636 - 641.
[Abstract] [PDF]

J. D. Ragland, R. C. Gur, J. Raz, L. Schroeder, C. G. Kohler, R. J. Smith, A. Alavi, and R. E. Gur
Effect of Schizophrenia on Frontotemporal Activity During Word Encoding and Recognition: A PET Cerebral Blood Flow Study
Am J Psychiatry, July 1, 2001; 158(7): 1114 - 1125.
[Abstract] [Full Text]

A. R. Gilbert, D. R. Rosenberg, K. Harenski, S. Spencer, J. A. Sweeney, and M. S. Keshavan
Thalamic Volumes in Patients With First-Episode Schizophrenia
Am J Psychiatry, April 1, 2001; 158(4): 618 - 624.
[Abstract] [Full Text]

W. Byne, M. S. Buchsbaum, E. Kemether, E. A. Hazlett, A. Shinwari, V. Mitropoulou, and L. J. Siever
Magnetic Resonance Imaging of the Thalamic Mediodorsal Nucleus and Pulvinar in Schizophrenia and Schizotypal Personality Disorder
Arch Gen Psychiatry, February 1, 2001; 58(2): 133 - 140.
[Abstract] [Full Text] [PDF]

U. Ettinger, X. A. Chitnis, V. Kumari, D. G. Fannon, A. L. Sumich, S. O’Ceallaigh, V. C. Doku, and T. Sharma
Magnetic Resonance Imaging of the Thalamus in First-Episode Psychosis
Am J Psychiatry, January 1, 2001; 158(1): 116 - 118.
[Abstract] [Full Text]

H. M. Ibrahim, A. J. Hogg Jr., D. J. Healy, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
Ionotropic Glutamate Receptor Binding and Subunit mRNA Expression in Thalamic Nuclei in Schizophrenia
Am J Psychiatry, November 1, 2000; 157(11): 1811 - 1823.
[Abstract] [Full Text]

G. J. Popken, W. E. Bunney Jr., S. G. Potkin, and E. G. Jones
Subnucleus-specific loss of neurons in medial thalamus of schizophrenics
PNAS, July 19, 2000; (2000) 150243397.
[Abstract] [Full Text]

A. R. Gilbert, G. J. Moore, M. S. Keshavan, L. A. D. Paulson, V. Narula, F. P. Mac Master, C. M. Stewart, and D. R. Rosenberg
Decrease in Thalamic Volumes of Pediatric Patients With Obsessive-compulsive Disorder Who Are Taking Paroxetine
Arch Gen Psychiatry, May 1, 2000; 57(5): 449 - 456.
[Abstract] [Full Text] [PDF]

M. SOYKA, T. ZETZSCHE, S. DRESEL, and K. TATSCH
FDG-PET and IBZM-SPECT Suggest Reduced Thalamic Activity but No Dopaminergic Dysfunction in Chronic Alcohol Hallucinosis
J Neuropsychiatry Clin Neurosci, May 1, 2000; 12(2): 287 - 288.
[Full Text] [PDF]

R. F. Deicken, C. Johnson, Y. Eliaz, and N. Schuff
Reduced Concentrations of Thalamic N-Acetylaspartate in Male Patients With Schizophrenia
Am J Psychiatry, April 1, 2000; 157(4): 644 - 647.
[Abstract] [Full Text]

W. G. Staal, H. E. Hulshoff Pol, H. G. Schnack, M. L.C. Hoogendoorn, K. Jellema, and R. S. Kahn
Structural Brain Abnormalities in Patients With Schizophrenia and Their Healthy Siblings
Am J Psychiatry, March 1, 2000; 157(3): 416 - 421.
[Abstract] [Full Text]

P. Sachdev and H. Brodaty
Quantitative Study of Signal Hyperintensities on T2-Weighted Magnetic Resonance Imaging in Late-Onset Schizophrenia
Am J Psychiatry, December 1, 1999; 156(12): 1958 - 1967.
[Abstract] [Full Text]

N. C. Andreasen
A Unitary Model of Schizophrenia: Bleuler's "Fragmented Phrene" as Schizencephaly
Arch Gen Psychiatry, September 1, 1999; 56(9): 781 - 787.
[Abstract] [Full Text] [PDF]

E. A. Hazlett, M. S. Buchsbaum, W. Byne, T.-C. Wei, J. Spiegel-Cohen, C. Geneve, R. Kinderlehrer, M. M. Haznedar, L. Shihabuddin, and L. J. Siever
Three-Dimensional Analysis With MRI and PET of the Size, Shape, and Function of the Thalamus in the Schizophrenia Spectrum
Am J Psychiatry, August 1, 1999; 156(8): 1190 - 1199.
[Abstract] [Full Text]

J. R. STEVENS
Epilepsy, Schizophrenia, and the Extended Amygdala
Ann. N.Y. Acad. Sci., June 29, 1999; 877(1): 548 - 561.
[Abstract] [Full Text] [PDF]

P. J. Harrison
The neuropathology of schizophrenia: A critical review of the data and their interpretation
Brain, April 1, 1999; 122(4): 593 - 624.
[Abstract] [Full Text] [PDF]

B. Crespo-Facorro, S. Paradiso, N. C. Andreasen, D. S. O'Leary, G. L. Watkins, L. L. Boles Ponto, and R. D. Hichwa
Recalling Word Lists Reveals "Cognitive Dysmetria" in Schizophrenia: A Positron Emission Tomography Study
Am J Psychiatry, March 1, 1999; 156(3): 386 - 392.
[Abstract] [Full Text]

A. Lavin and A. A. Grace
Dopamine Modulates the Responsivity of Mediodorsal Thalamic Cells Recorded In Vitro
J. Neurosci., December 15, 1998; 18(24): 10566 - 10578.
[Abstract] [Full Text] [PDF]

R. E. Gur, V. Maany, P. D. Mozley, C. Swanson, W. Bilker, and R. C. Gur
Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia
Am J Psychiatry, December 1, 1998; 155(12): 1711 - 1717.
[Abstract] [Full Text]

W. G. Staal, H. E. H. Pol, H. Schnack, A. C. van der Schot, and R. S. Kahn
Partial Volume Decrease of the Thalamus in Relatives of Patients With Schizophrenia
Am J Psychiatry, December 1, 1998; 155(12): 1784 - 1786.
[Abstract] [Full Text]

M. S. Keshavan, C. F. Reynolds III, J. M. Miewald, D. M. Montrose, J. A. Sweeney, R. C. Vasko Jr, and D. J. Kupfer
Delta Sleep Deficits in Schizophrenia: Evidence From Automated Analyses of Sleep Data
Arch Gen Psychiatry, May 1, 1998; 55(5): 443 - 448.
[Abstract] [Full Text] [PDF]

G. J. Popken, W. E. Bunney Jr., S. G. Potkin, and E. G. Jones
Subnucleus-specific loss of neurons in medial thalamus of schizophrenics
PNAS, August 1, 2000; 97(16): 9276 - 9280.
[Abstract] [Full Text] [PDF]

Get information about faster international access.