Am J Psychiatry 1996; 153:1625-1627
Copyright © 1996 by American Psychiatric Association
Fluoxetine augmentation of clozapine treatment in patients with schizophrenia
RW Buchanan, B Kirkpatrick, N Bryant, P Ball and A Breier
Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
OBJECTIVE: The authors examined the efficacy of fluoxetine augmentation of
clozapine treatment response in schizophrenic outpatients who, despite
adequate treatment with clozapine, continued to exhibit persistent positive
or negative symptoms. METHOD: Thirty-three patients completed on 8-week,
double-blind, parallel-groups comparison of adjunctive fluoxetine and
placebo. RESULTS: There were no significant differences in positive,
negative, depressive, or obsessive-compulsive symptoms between patients
given adjunctive fluoxetine or placebo. CONCLUSIONS: These results suggest
that fluoxetine is not effective in augmenting clozapine treatment
response.
