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Am J Psychiatry 1996; 153:1548-1553
Copyright © 1996 by American Psychiatric Association
Cortical gray matter volume deficit in patients with first-episode schizophrenia
KO Lim, W Tew, M Kushner, K Chow, B Matsumoto and LE DeLisi
Psychiatry Service (116-A3), VA Palo Alto Health Care System, CA 94304, USA. lim@isl.stanford.edu
OBJECTIVE: A cortical gray matter deficit has been found in cross-
sectional studies of patients with chronic schizophrenia. The purpose of
this study was to examine whether this deficit is present early in the
course of illness. METHOD: The authors measured cortical gray matter volume
on magnetic resonance images acquired within 6 months of onset of illness
from 22 patients with first-episode schizophrenia and 51 age-matched
comparison subjects from the Stony Brook First Episode Study. RESULTS: A
significant cortical gray matter deficit and lateral ventricular
enlargement were found in schizophrenic patients relative to the comparison
group. CONCLUSIONS: The presence of the cortical gray matter deficit close
to onset of illness supports the role of preexisting structural brain
deficits in the genesis of schizophrenia.
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