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Am J Psychiatry 1996; 153:50-56
Copyright © 1996 by American Psychiatric Association
Superior temporal gyrus volume in schizophrenia: a study using MRI morphometry assisted by surface rendering
JJ Kulynych, K Vladar, DW Jones and DR Weinberger
Clinical Brain Disorders Branch, NIMH, NIH, Washington, DC, USA.
OBJECTIVE: Interpretation of the literature concerning superior temporal
gyrus volume in patients with schizophrenia is complicated by
methodological variation between studies and by the difficulty of
identifying gyral boundaries in serial sections. METHOD: With the aid of
three-dimensional cortical renderings, the authors developed a morphometric
approach in which information from the cortical surface is incorporated
into gyral boundary decisions. Using this technique, they assessed superior
temporal gyrus volume in young, right-handed male patients with
schizophrenia and in right-handed male comparison subjects. They also
compared their technique with existing slice-based morphometric methods by
using previously reported subcortical landmarks to define the gyral
boundaries. RESULTS: There was no significant main effect of diagnosis and
no significant diagnosis-by-hemisphere interaction. Significant leftward
laterality was present only among comparison subjects. Leftward superior
temporal gyrus laterality did not correlate with leftward laterality of the
planum temporale. No significant reduction in superior temporal gyrus
volume was revealed in the patients. No significant leftward laterality was
detected with the slice-based technique, suggesting that a significant
portion of superior temporal gyrus tissue is omitted with this approach.
The lack of findings could not be explained by a general absence of
morphometric abnormalities in this group of subjects because the patients
had significantly larger lateral ventricles. CONCLUSIONS: Significant
reduction in the superior temporal gyrus volume was not confirmed in this
group of patients with schizophrenia, probably because of the small effect
size of this finding. Methodological variation is an important factor in
determining superior temporal gyrus volume on magnetic resonance imaging
scans.
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