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Am J Psychiatry 1995; 152:1368-1371
Copyright © 1995 by American Psychiatric Association
Sertraline for social phobia: a double-blind, placebo-controlled crossover study
DJ Katzelnick, KA Kobak, JH Greist, JW Jefferson, JM Mantle and RC Serlin
Foundation for Health, Research and Education, Madison, WI 53717, USA.
OBJECTIVE: The authors examined the efficacy of sertraline in the treatment
of social phobia. METHOD: In a double-blind crossover study, 12 outpatients
were randomly assigned to 10 weeks of sertraline (50-200 mg/day, flexible
dosing) and 10 weeks of placebo. RESULTS: A statistically significant
improvement in scores on the Liebowitz Social Anxiety Scale was found with
sertraline but not with placebo. There was no significant difference
between scores obtained with computer- and clinician-administered versions
of the Liebowitz Social Anxiety Scale, and the majority of patients
preferred to be interviewed by the computer. CONCLUSIONS: Sertraline seems
a safe and effective treatment for social phobia, and computer
administration may be a preferable mode of assessment with socially phobic
patients.
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