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Am J Psychiatry 1995; 152:1349-1357
Copyright © 1995 by American Psychiatric Association
The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
PN Tariot, JL Mack, MB Patterson, SD Edland, MF Weiner, G Fillenbaum, L Blazina, L Teri, E Rubin and JA Mortimer
University of Rochester School of Medicine, N.Y., USA.
OBJECTIVE: The purpose of the study was to develop a standardized
instrument, the Behavior Rating Scale for Dementia, for rating
psychopathology in patients with probable Alzheimer's disease and to
conduct a multicenter pilot study of this instrument. METHOD: The rating
scale was developed collaboratively on the basis of clinical experience and
existing instruments. Items were scaled according to frequency of
psychopathology and were administered to an informant who was familiar with
the subject. The scale was administered in a standardized manner by trained
examiners who had met predetermined certification standards. The study
group consisted of 303 subjects with probable Alzheimer's disease who had
undergone standardized clinical evaluations by the Consortium to Establish
a Registry for Alzheimer's Disease. RESULTS: Subjects had an average of 15
problems rated as present in the preceding month. Wide variability in the
nature of disturbances was found, with a number of items rated as present
since the illness began but not in the past month. Interrater agreement was
high. Factor analysis suggested eight preliminary factors that mapped onto
clinically relevant domains: depressive features, psychotic features,
defective self-regulation, irritability/agitation, vegetative features,
apathy, aggression, and affective lability. CONCLUSIONS: The Behavior
Rating Scale for Dementia provides a standardized, reliable measure that
can be administered to caregivers of demented subjects. On the basis of the
present study, the scale has been revised slightly. After additional
studies in progress, the Behavior Rating Scale for Dementia will be
available for general use in assessing a wide range of psychopathology in
dementia.
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