|
| | |
|
Am J Psychiatry 1995; 152:1219-1221
Copyright © 1995 by American Psychiatric Association
Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism
S Higuchi, S Matsushita, M Murayama, S Takagi and M Hayashida
National Insitute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan.
OBJECTIVE: The authors studied a large number of Japanese alcoholic
patients and comparison subjects to establish the genotype frequencies of
alcohol dehydrogenase-2 (ADH2) and mitochondrial aldehyde dehydrogenase
(ALDH2) and to quantify the relative risk for alcoholism from the results.
METHOD: The subjects were 655 alcoholic patients and 461 comparison
subjects. ADH2 and ALDH2 were genotyped by the combination of polymerase
chain reaction and hybridization methods. RESULTS: Active ALDH2 and usual
ADH2 were significantly more frequent in the alcoholic patients. Inactive
ALDH2 was not always associated with a low risk of alcoholism, and active
ALDH2 was not always associated with high risk. In individuals with
heterozygous inactive ALDH2 and usual ADH2, the odds ratio for alcoholism
was high. CONCLUSIONS: The risk for alcoholism in Japanese has been
accurately estimated on the basis of the genotype frequencies of ADH2 and
ALDH2. Many Japanese may be protected from alcoholism by inactive ALDH2 and
by higher frequencies of atypical ADH2.
This article has been cited by other articles:
|
|
|
|
 
T. Asakage, A. Yokoyama, T. Haneda, M. Yamazaki, M. Muto, T. Yokoyama, H. Kato, H. Igaki, T. Tsujinaka, Y. Kumagai, et al.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma
Carcinogenesis,
April 1, 2007;
28(4):
865 - 874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. Hahn, S.-Y. Huang, H.-C. Ko, C.-H. Hsieh, I-H. Lee, T.-L. Yeh, Y.-K. Yang, J.-F. Lee, W.-W. Lin, and R.-B. Lu
Acetaldehyde Involvement in Positive and Negative Alcohol Expectancies in Han Chinese Persons With Alcoholism.
Arch Gen Psychiatry,
July 1, 2006;
63(7):
817 - 823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. HIGUCHI, S. MATSUSHITA, T. MASAKI, A. YOKOYAMA, M. KIMURA, G. SUZUKI, and H. MOCHIZUKI
Influence of Genetic Variations of Ethanol-Metabolizing Enzymes on Phenotypes of Alcohol-Related Disorders
Ann. N.Y. Acad. Sci.,
October 1, 2004;
1025(1):
472 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Miyasaka, Y. Yoshida, S. Matsushita, S. Higuchi, K. Maruyama, N. Niino, F. Ando, H. Shimokata, S. Ohta, and A. Funakoshi
ASSOCIATION OF CHOLECYSTOKININ-A RECEPTOR GENE POLYMORPHISM WITH ALCOHOL DEPENDENCE IN A JAPANESE POPULATION
Alcohol Alcohol.,
January 1, 2004;
39(1):
25 - 28.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yokoyama, A. Yokoyama, H. Kato, T. Tsujinaka, M. Muto, T. Omori, T. Haneda, Y. Kumagai, H. Igaki, M. Yokoyama, et al.
Alcohol Flushing, Alcohol and Aldehyde Dehydrogenase Genotypes, and Risk for Esophageal Squamous Cell Carcinoma in Japanese Men
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2003;
12(11):
1227 - 1233.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Tamakoshi, N. Hamajima, H. Kawase, K. Wakai, N. Katsuda, T. Saito, H. Ito, K. Hirose, T. Takezaki, and K. Tajima
DUPLEX POLYMERASE CHAIN REACTION WITH CONFRONTING TWO-PAIR PRIMERS (PCR-CTPP) FOR GENOTYPING ALCOHOL DEHYDROGENASE {beta} SUBUNIT (ADH2) AND ALDEHYDE DEHYDROGENASE 2 (ALDH2)
Alcohol Alcohol.,
September 1, 2003;
38(5):
407 - 410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Yokoyama and T. Omori
Genetic Polymorphisms of Alcohol and Aldehyde Dehydrogenases and Risk for Esophageal and Head and Neck Cancers
Jpn. J. Clin. Oncol.,
March 1, 2003;
33(3):
111 - 121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Kalivas
Predisposition to Addiction: Pharmacokinetics, Pharmacodynamics, and Brain Circuitry
Am J Psychiatry,
January 1, 2003;
160(1):
1 - 2.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Wall, L. G. Carr, and C. L. Ehlers
Protective Association of Genetic Variation in Alcohol Dehydrogenase With Alcohol Dependence in Native American Mission Indians
Am J Psychiatry,
January 1, 2003;
160(1):
41 - 46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Yokoyama, H. Watanabe, H. Fukuda, T. Haneda, H. Kato, T. Yokoyama, T. Muramatsu, H. Igaki, and Y. Tachimori
Multiple Cancers Associated with Esophageal and Oropharyngolaryngeal Squamous Cell Carcinoma and the Aldehyde Dehydrogenase-2 Genotype in Male Japanese Drinkers
Cancer Epidemiol. Biomarkers Prev.,
September 1, 2002;
11(9):
895 - 900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Matsuo, N. Hamajima, M. Shinoda, S. Hatooka, M. Inoue, T. Takezaki, and K. Tajima
Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer
Carcinogenesis,
June 1, 2001;
22(6):
913 - 916.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Radel and D. Goldman
Pharmacogenetics of Alcohol Response and Alcoholism: The Interplay of Genes and Environmental Factors in Thresholds for Alcoholism
Drug Metab. Dispos.,
April 1, 2001;
29(4):
489 - 494.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Yokoyama, T. Muramatsu, T. Omori, T. Yokoyama, S. Matsushita, S. Higuchi, K. Maruyama, and H. Ishii
Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics
Carcinogenesis,
March 1, 2001;
22(3):
433 - 439.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. K. Farren and K. F. Tipton
TRAIT MARKERS FOR ALCOHOLISM: CLINICAL UTILITY
Alcohol Alcohol.,
September 1, 1999;
34(5):
649 - 665.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
