Am J Psychiatry 1995; 152:1210-1212
Copyright © 1995 by American Psychiatric Association
Further evidence of a dose-response threshold for haloperidol in psychosis
CK Stone, DL Garve, J Griffith, J Hirschowitz and J Bennett
Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.
OBJECTIVE: The authors' goal was to determine whether higher doses of
haloperidol improve antipsychotic response. METHOD: During a 2-week,
double-blind, randomized fixed-dose study, 24 psychotic patients were given
4, 10, or 40 mg/day of haloperidol. RESULTS: No clinically relevant
difference between groups in favor of the higher antipsychotic doses could
be detected. CONCLUSIONS: Doses of 4 mg/day of haloperidol appear to be as
effective as higher doses in the treatment of psychosis.
