|
| | |
|
Am J Psychiatry 1995; 152:987-994
Copyright © 1995 by American Psychiatric Association
Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia
EH Aylward, PD Brettschneider, JC McArthur, GJ Harris, TE Schlaepfer, JD Henderer, PE Barta, AY Tien and GD Pearlson
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
OBJECTIVE: The authors recently reported smaller basal ganglia volumes for
patients with HIV-associated dementia than for HIV-infected patients
without dementia and a seronegative comparison group. The purpose of the
current study was to determine whether HIV dementia is associated with
volume reductions in other brain regions. METHOD: The authors measured
volumes of CSF and gray and white tissue on cranial magnetic resonance
images from homosexual men who were 1) infected with HIV with
HIV-associated dementia complex, 2) infected with HIV without dementia, and
3) HIV seronegative. RESULTS: Results suggest that loss of white matter
occurs with HIV infection and is more severe in HIV- positive patients with
dementia than in those without dementia. There was some generalized volume
reduction in gray matter in HIV-positive demented patients, although group
differences did not reach significance when adjusted for age. Volume of
posterior cortex, however, was significantly smaller among HIV-positive
patients with dementia than in either remaining group. There were no
significant differences between HIV-positive nondemented patients and
HIV-negative subjects in these regions. CONCLUSIONS: In conjunction with
findings from previous research, the authors conclude that HIV dementia is
associated with specific gray matter volume reduction in basal ganglia and
posterior cortex, as well as with generalized volume reduction of white
matter.
This article has been cited by other articles:
|
|
|
|
 
B. M. Ances, A. C. Roc, J. Wang, M. Korczykowski, J. Okawa, J. Stern, J. Kim, R. Wolf, K. Lawler, D. L. Kolson, et al.
Caudate blood flow and volume are reduced in HIV+ neurocognitively impaired patients
Neurology,
March 28, 2006;
66(6):
862 - 866.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Jernigan, A. C. Gamst, S. L. Archibald, C. Fennema-Notestine, M. R. Mindt, T. L. Marcotte, R. K. Heaton, R. J. Ellis, and I. Grant
Effects of Methamphetamine Dependence and HIV Infection on Cerebral Morphology
Am J Psychiatry,
August 1, 2005;
162(8):
1461 - 1472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Rostasy, L Monti, S A Lipton, J C Hedreen, R G Gonzalez, and B A Navia
HIV leucoencephalopathy and TNF{alpha} expression in neurones
J. Neurol. Neurosurg. Psychiatry,
July 1, 2005;
76(7):
960 - 964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Fernandez
Ten Myths About HIV Infection and Aids
Focus,
April 1, 2005;
3(2):
184 - 193.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Archibald, E. Masliah, C. Fennema-Notestine, T. D. Marcotte, R. J. Ellis, J. A. McCutchan, R. K. Heaton, I. Grant, M. Mallory, A. Miller, et al.
Correlation of In Vivo Neuroimaging Abnormalities With Postmortem Human Immunodeficiency Virus Encephalitis and Dendritic Loss
Arch Neurol,
March 1, 2004;
61(3):
369 - 376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ge, D. L. Kolson, J. S. Babb, L. J. Mannon, and R. I. Grossman
Whole Brain Imaging of HIV-Infected Patients: Quantitative Analysis of Magnetization Transfer Ratio Histogram and Fractional Brain Volume
AJNR Am. J. Neuroradiol.,
January 1, 2003;
24(1):
82 - 87.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Patel, D. L. Kolson, G. Glosser, I. Matozzo, Y. Ge, J. S. Babb, L. J. Mannon, and R. I. Grossman
Correlation between Percentage of Brain Parenchymal Volume and Neurocognitive Performance in HIV-Infected Patients
AJNR Am. J. Neuroradiol.,
April 1, 2002;
23(4):
543 - 549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Berger, A. Nath, R. N. Greenberg, A. H. Andersen, R. A. Greene, A. Bognar, and M. J. Avison
Cerebrovascular changes in the basal ganglia with HIV dementia
Neurology,
February 22, 2000;
54(4):
921 - 926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Chang, T. Ernst, M. Leonido-Yee, and O. Speck
Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex
Neurology,
January 25, 2000;
54(2):
389 - 389.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Wiseman, J. A. Sanchez, C. Buechel, M. A. Mintun, O. L. Lopez, D. Milko, and J. T. Becker
Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection
J Neuropsychiatry Clin Neurosci,
May 1, 1999;
11(2):
222 - 233.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. C. Stout, R. J. Ellis, T. L. Jernigan, S. L. Archibald, I. Abramson, T. Wolfson, J. A. McCutchan, M. R. Wallace, J. H. Atkinson, I. Grant, et al.
Progressive Cerebral Volume Loss in Human Immunodeficiency Virus Infection: A Longitudinal Volumetric Magnetic Resonance Imaging Study
Arch Neurol,
February 1, 1998;
55(2):
161 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
