Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients



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	Articles by Wallace, A. E.
	Articles by West, A. N.

Am J Psychiatry 1995; 152:929-931
Copyright © 1995 by American Psychiatric Association

BRIEF REPORTS

Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients

AE Wallace, LL Kofoed and AN West
VA Medical Centers in White River Junction, Vt. 05009, USA.

OBJECTIVE: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients. METHOD: Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial. RESULTS: Statistically and clinically significant treatment responses were found. CONCLUSIONS: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.

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