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Am J Psychiatry 1995; 152:907-913
Copyright © 1995 by American Psychiatric Association
Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates
PT Mehlman, JD Higley, I Faucher, AA Lilly, DM Taub, J Vickers, SJ Suomi and M Linnoila
Laboratory Animal Breeders and Services, Inc., Yemassee, SC 29945, USA.
OBJECTIVE: The purpose of this study was to examine the relationship
between behavior and serotonin in nonhuman primates. METHOD: During a
routine capture and medical examination, 26 adolescent male rhesus macaques
(Macaca mulatta) were selected as subjects from a free-ranging population
of 4,500 rhesus monkeys inhabiting a 475-acre sea island. Blood samples (N
= 23) and CSF samples (N = 22) were obtained, and each subject was fitted
with a radio transmitter collar for rapid location. The subjects were
released into their social groups, and quantitative behavioral observations
were made over a 3-month period. RESULTS: CSF 5- hydroxyindoleacetic acid
(5-HIAA) concentration was positively correlated with three measures of
sociality: 1) total time spent grooming others, 2) total time spent in
close proximity to other group members, and 3) mean number of neighbors
within a 5-m radius. In addition, CSF 5-HIAA concentration was positively
correlated with age at emigration from the natal group (in months).
CONCLUSIONS: In adolescent male rhesus macaques living in naturalistic
settings, CSF 5- HIAA concentration is positively correlated with
affiliative sociality. Rhesus males with low CSF 5-HIAA concentrations
exhibit less social competence and emigrate from their social groups at a
younger age than do males with higher concentrations of CSF 5-HIAA.
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