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Am J Psychiatry 1995; 152:623-625
Copyright © 1995 by American Psychiatric Association
Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder
G Perna, S Cocchi, A Bertani, C Arancio and L Bellodi
Department of Neuropsychiatric Sciences, Instituto Scientifico H. San Raffaele, University of Milan, Italy.
OBJECTIVE: The authors tested the hypothesis that hyperreactivity to CO2 in
healthy subjects represents an underlying familial vulnerability to panic
disorder. METHOD: One vital-capacity inhalation of 35% CO2 and 65% O2 was
administered to each of 84 patients with panic disorder, 23 healthy
first-degree relatives of probands with panic disorder, and 44 healthy
subjects with no family history of panic disorder. RESULTS: The
first-degree relatives of the probands with panic disorder reacted
significantly more than the healthy subjects and significantly less than
the probands. CONCLUSIONS: These findings suggest an association between
family history of panic disorder and hyperreactivity to 35% CO2 in healthy
subjects.
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