|
| | |
|
Am J Psychiatry 1995; 152:444-446
Copyright © 1995 by American Psychiatric Association
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis
PF Renshaw, DA Yurgelun-Todd, M Tohen, S Gruber and BM Cohen
McLean Brain Imaging Center, McLean Hospital, Belmont, MA 02178.
OBJECTIVE: The authors measured the ratio of N-acetyl aspartate (a putative
neuronal marker) to creatine-phosphocreatine in patients with first-episode
psychosis by using proton magnetic resonance spectroscopy (MRS). METHOD:
Temporal lobe 1H MRS was performed bilaterally on 13 patients with
first-episode psychosis and 15 comparison subjects. The N- acetyl
aspartate/creatine-phosphocreatine and choline/creatine- phosphocreatine
ratios were determined. RESULTS: The N-acetyl
aspartate/creatine-phosphocreatine ratio of the psychotic patients was
significantly lower than that of the comparison subjects. CONCLUSIONS:
These preliminary data suggest that abnormalities in temporal lobe N-
acetyl aspartate concentration are present early in psychotic illness.
This article has been cited by other articles:
|
|
|
|
 
R. F. Deicken, M. P. Pegues, S. Anzalone, R. Feiwell, and B. Soher
Lower Concentration of Hippocampal N-Acetylaspartate in Familial Bipolar I Disorder
Am J Psychiatry,
May 1, 2003;
160(5):
873 - 882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bertolino, J. L. Roffman, B. K. Lipska, P. van Gelderen, A. Olson, and D. R. Weinberger
Reduced N-Acetylaspartate in Prefrontal Cortex of Adult Rats with Neonatal Hippocampal Damage
Cereb Cortex,
September 1, 2002;
12(9):
983 - 990.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Foong, M. R. Symms, G. J. Barker, M. Maier, F. G. Woermann, D. H. Miller, and M. A. Ron
Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging
Brain,
May 1, 2001;
124(5):
882 - 892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. F. BUCKLEY and L. FRIEDMAN
Magnetic resonance spectroscopy: Bridging the neurochemistry and neuroanatomy of schizophrenia
The British Journal of Psychiatry,
March 1, 2000;
176(3):
203 - 205.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bertolino, G. Esposito, J. H. Callicott, V. S. Mattay, J. D. Van Horn, J. A. Frank, K. F. Berman, and D. R. Weinberger
Specific Relationship Between Prefrontal NeuronalN-Acetylaspartate and Activation of the Working Memory Cortical Network in Schizophrenia
Am J Psychiatry,
January 1, 2000;
157(1):
26 - 33.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J Foong, M Maier, G J Barker, S Brocklehurst, D H Miller, and M A Ron
In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging
J. Neurol. Neurosurg. Psychiatry,
January 1, 2000;
68(1):
70 - 74.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. Sanacora, D. Rothman, and J. H. Krystal
Applications of Magnetic Resonance Spectroscopy to Psychiatry
Neuroscientist,
May 1, 1999;
5(3):
192 - 196.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Harrison
The neuropathology of schizophrenia: A critical review of the data and their interpretation
Brain,
April 1, 1999;
122(4):
593 - 624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bertolino, S. Kumra, J. H. Callicott, V. S. Mattay, R. M. Lestz, L. Jacobsen, l. S. Barnett, J. H. Duyn, J. A. Frank, J. L. Rapoport, et al.
Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic Imaging
Am J Psychiatry,
October 1, 1998;
155(10):
1376 - 1383.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. O. Lim, E. Adalsteinsson, D. Spielman, E. V. Sullivan, M. J. Rosenbloom, and A. Pfefferbaum
Proton Magnetic Resonance Spectroscopic Imaging of Cortical Gray and White Matter in Schizophrenia
Arch Gen Psychiatry,
April 1, 1998;
55(4):
346 - 352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. S. Jarboe and C. D. Kilts
Diagnosis, Neurobiology, and Treatment of First-episode Schizophrenia
Journal of the American Psychiatric Nurses Association,
February 1, 1998;
4(1):
S2 - S9.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
