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Am J Psychiatry 1995; 152:419-423
Copyright © 1995 by American Psychiatric Association
Low serum cholesterol level and attempted suicide
JA Golier, PM Marzuk, AC Leon, C Weiner and K Tardiff
Payne Whitney Clinic, New York Hospital.
OBJECTIVE: Several studies suggest that a low cholesterol concentration is
associated with a greater than normal risk of mortality from suicide. The
authors sought to determine whether a low cholesterol level is associated
with a history of serious suicide attempts among psychiatric inpatients.
METHOD: Lifetime history of attempted suicide of 650 patients, aged 18-59
years, consecutively admitted to a psychiatric hospital was assessed by
semistructured interview. The seriousness of an attempt was rated on the
basis of the resulting medical injury. Serum cholesterol levels, obtained
from the admission biochemical profiles, were divided into quartiles.
RESULTS: Compared to men with low cholesterol levels (defined as less than
or equal to the 25th percentile), men with cholesterol levels above the
25th percentile were less likely to have ever made a serious suicide
attempt when age, weight, race, socioeconomic status, alcohol use, and
depression were controlled for. There was no association between
cholesterol level and attempted suicide in women. CONCLUSIONS: Male
psychiatric patients with low cholesterol levels were twice as likely to
have ever made a medically serious suicide attempt than men with
cholesterol levels above the 25th percentile. Low cholesterol concentration
should be further investigated as a potential biological marker of suicide
risk.
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